Mechanism of proteinuria in nephrotic syndrome.

Z. Ota, Kenichi Shikata, K. Ota

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We developed a "tissue negative staining method" to observe the molecular-level ultrastructure in situ in any portion of the ultrathin sections routinely prepared for electron microscopy. This method was used in electron microscopy of the glomerular basement membranes (GBM). The GBM in patients with nephrotic syndrome was discovered to possess a tunnel structure, designated as "nephrotic tunnel", with lumen large enough to allow free passage of protein molecules. This tunnel seemed to be involved in the etiology of nephrotic syndrome. This new method appears to be applicable to a variety of purposes in biological studies.

Original languageEnglish
Pages (from-to)483-487
Number of pages5
JournalActa Medica Okayama
Volume46
Issue number6
Publication statusPublished - Dec 1992

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Nephrotic Syndrome
Proteinuria
Tunnels
Glomerular Basement Membrane
Electron microscopy
Electron Microscopy
Negative Staining
Tissue
Molecules
Proteins
Basement Membrane

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Mechanism of proteinuria in nephrotic syndrome. / Ota, Z.; Shikata, Kenichi; Ota, K.

In: Acta Medica Okayama, Vol. 46, No. 6, 12.1992, p. 483-487.

Research output: Contribution to journalArticle

Ota, Z, Shikata, K & Ota, K 1992, 'Mechanism of proteinuria in nephrotic syndrome.', Acta Medica Okayama, vol. 46, no. 6, pp. 483-487.
Ota, Z. ; Shikata, Kenichi ; Ota, K. / Mechanism of proteinuria in nephrotic syndrome. In: Acta Medica Okayama. 1992 ; Vol. 46, No. 6. pp. 483-487.
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