Mechanism of hematuria - I. Electron microscopic demonstration of the passage of a red blood cell through a glomerular capillary wall in rat masugi nephritis

Hirofumi Makino, Shigeaki Nishimura, Kenji Soda, Michio Takaoka, Tetsuji Kaneshige, Zensuke Ota

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Masugi nehpritis was induced in Sprague-Dawley rats by an intravenous injection of rabbit anti-rat kidney serum. In the autologous phase of the disease, three of 18 rats manifested continuous hematuria. Ultrastructural examination of renal glomeruli by transmission and scanning microscopy revealed gaps in the basement membranes, and the transcapillary passage of red blood cells through the discontinuous regions in the hematuric rats. Control animals revealed no gaps in the glomerular basement membranes regardless of the method used in their preparation for electron microscopy. These data support the hypothesis that hematuria is a result of the passage of red blood cells through gaps in the glomerular basement membrane in Masugi nephritis.

Original languageEnglish
Pages (from-to)199-208
Number of pages10
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Volume50
Issue number1
DOIs
Publication statusPublished - Dec 1 1986

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Nephritis
Hematuria
Glomerular Basement Membrane
Erythrocytes
Electrons
Kidney
Basement Membrane
Intravenous Injections
Sprague Dawley Rats
Microscopy
Electron Microscopy
Rabbits
Serum

Keywords

  • Acellular kidney
  • Glomerular basement membrane
  • Hematuria
  • Nephrotoxic nephritis
  • Scanning electron microscopy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Mechanism of hematuria - I. Electron microscopic demonstration of the passage of a red blood cell through a glomerular capillary wall in rat masugi nephritis. / Makino, Hirofumi; Nishimura, Shigeaki; Soda, Kenji; Takaoka, Michio; Kaneshige, Tetsuji; Ota, Zensuke.

In: Virchows Archiv B Cell Pathology Including Molecular Pathology, Vol. 50, No. 1, 01.12.1986, p. 199-208.

Research output: Contribution to journalArticle

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