Mechanism of Enhancement Effect of Dendrimer on Transdermal Drug Permeation through Polyhydroxyalkanoate Matrix

Zhixiong Wang, Yoshiaki Itoh, Yoshifumi Hosaka, Ichiro Kobayashi, Yoshihisa Nakano, Isamu Maeda, Fusako Umeda, Junji Yamakawa, Mari Nishimine, Tomoyoshi Suenobu, Shunichi Fukuzumi, Masaya Kawase, Kiyohito Yagi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The possible application of polyhydroxyalkanoate (PHA) in transdermal drug delivery systems (TDDSs) for tamsulosin was previously reported. PHAs containing the drugs, ketoprofen, clonidine and tamsulosin showed good adhesiveness to the skin model used, that is, shed snake skin, and dispersed well all model drugs tested. The model drugs hardly permeated through snake skin in solution form. However, these drugs permeated well through snake skin from the PHA matrix. It was previously reported that the addition of a dendrimer, a polymeric permeation enhancer, is effective for the TDDS for tamsulosin to establish an effective clinical TDDS. The effect of dendrimer addition was examined in TDDSs for ketoprofen and clonidine. The dendrimer added did not show an enhancement effect on the TDDSs for the two drugs. To investigate the mechanism of the enhancement effect of a dendrimer on the tamsulosin TDDS, X-ray analyses were performed. With dendrimer addition, drug crystallization in PHA was promoted. The crystal in PHA had highly ordered and changed its space group. These findings are very important for exploiting high-performance PHA-based TDDSs.

Original languageEnglish
Pages (from-to)537-540
Number of pages4
JournalJournal of Bioscience and Bioengineering
Volume96
Issue number6
DOIs
Publication statusPublished - 2003

Fingerprint

Polyhydroxyalkanoates
tamsulosin
Dendrimers
Drug Delivery Systems
Permeation
Snakes
Pharmaceutical Preparations
Skin
Ketoprofen
Clonidine
Adhesiveness
Crystallization
X-Rays
X rays
Crystals

Keywords

  • Dendrimer
  • Enhancing effect
  • Polyhydroxyalkanoate
  • Transdermal drug delivery
  • X-ray diffraction

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

Cite this

Mechanism of Enhancement Effect of Dendrimer on Transdermal Drug Permeation through Polyhydroxyalkanoate Matrix. / Wang, Zhixiong; Itoh, Yoshiaki; Hosaka, Yoshifumi; Kobayashi, Ichiro; Nakano, Yoshihisa; Maeda, Isamu; Umeda, Fusako; Yamakawa, Junji; Nishimine, Mari; Suenobu, Tomoyoshi; Fukuzumi, Shunichi; Kawase, Masaya; Yagi, Kiyohito.

In: Journal of Bioscience and Bioengineering, Vol. 96, No. 6, 2003, p. 537-540.

Research output: Contribution to journalArticle

Wang, Z, Itoh, Y, Hosaka, Y, Kobayashi, I, Nakano, Y, Maeda, I, Umeda, F, Yamakawa, J, Nishimine, M, Suenobu, T, Fukuzumi, S, Kawase, M & Yagi, K 2003, 'Mechanism of Enhancement Effect of Dendrimer on Transdermal Drug Permeation through Polyhydroxyalkanoate Matrix', Journal of Bioscience and Bioengineering, vol. 96, no. 6, pp. 537-540. https://doi.org/10.1263/jbb.96.537
Wang, Zhixiong ; Itoh, Yoshiaki ; Hosaka, Yoshifumi ; Kobayashi, Ichiro ; Nakano, Yoshihisa ; Maeda, Isamu ; Umeda, Fusako ; Yamakawa, Junji ; Nishimine, Mari ; Suenobu, Tomoyoshi ; Fukuzumi, Shunichi ; Kawase, Masaya ; Yagi, Kiyohito. / Mechanism of Enhancement Effect of Dendrimer on Transdermal Drug Permeation through Polyhydroxyalkanoate Matrix. In: Journal of Bioscience and Bioengineering. 2003 ; Vol. 96, No. 6. pp. 537-540.
@article{c9516b8667e84df79269a7bb9fdb5a6b,
title = "Mechanism of Enhancement Effect of Dendrimer on Transdermal Drug Permeation through Polyhydroxyalkanoate Matrix",
abstract = "The possible application of polyhydroxyalkanoate (PHA) in transdermal drug delivery systems (TDDSs) for tamsulosin was previously reported. PHAs containing the drugs, ketoprofen, clonidine and tamsulosin showed good adhesiveness to the skin model used, that is, shed snake skin, and dispersed well all model drugs tested. The model drugs hardly permeated through snake skin in solution form. However, these drugs permeated well through snake skin from the PHA matrix. It was previously reported that the addition of a dendrimer, a polymeric permeation enhancer, is effective for the TDDS for tamsulosin to establish an effective clinical TDDS. The effect of dendrimer addition was examined in TDDSs for ketoprofen and clonidine. The dendrimer added did not show an enhancement effect on the TDDSs for the two drugs. To investigate the mechanism of the enhancement effect of a dendrimer on the tamsulosin TDDS, X-ray analyses were performed. With dendrimer addition, drug crystallization in PHA was promoted. The crystal in PHA had highly ordered and changed its space group. These findings are very important for exploiting high-performance PHA-based TDDSs.",
keywords = "Dendrimer, Enhancing effect, Polyhydroxyalkanoate, Transdermal drug delivery, X-ray diffraction",
author = "Zhixiong Wang and Yoshiaki Itoh and Yoshifumi Hosaka and Ichiro Kobayashi and Yoshihisa Nakano and Isamu Maeda and Fusako Umeda and Junji Yamakawa and Mari Nishimine and Tomoyoshi Suenobu and Shunichi Fukuzumi and Masaya Kawase and Kiyohito Yagi",
year = "2003",
doi = "10.1263/jbb.96.537",
language = "English",
volume = "96",
pages = "537--540",
journal = "Journal of Bioscience and Bioengineering",
issn = "1389-1723",
publisher = "The Society for Biotechnology, Japan",
number = "6",

}

TY - JOUR

T1 - Mechanism of Enhancement Effect of Dendrimer on Transdermal Drug Permeation through Polyhydroxyalkanoate Matrix

AU - Wang, Zhixiong

AU - Itoh, Yoshiaki

AU - Hosaka, Yoshifumi

AU - Kobayashi, Ichiro

AU - Nakano, Yoshihisa

AU - Maeda, Isamu

AU - Umeda, Fusako

AU - Yamakawa, Junji

AU - Nishimine, Mari

AU - Suenobu, Tomoyoshi

AU - Fukuzumi, Shunichi

AU - Kawase, Masaya

AU - Yagi, Kiyohito

PY - 2003

Y1 - 2003

N2 - The possible application of polyhydroxyalkanoate (PHA) in transdermal drug delivery systems (TDDSs) for tamsulosin was previously reported. PHAs containing the drugs, ketoprofen, clonidine and tamsulosin showed good adhesiveness to the skin model used, that is, shed snake skin, and dispersed well all model drugs tested. The model drugs hardly permeated through snake skin in solution form. However, these drugs permeated well through snake skin from the PHA matrix. It was previously reported that the addition of a dendrimer, a polymeric permeation enhancer, is effective for the TDDS for tamsulosin to establish an effective clinical TDDS. The effect of dendrimer addition was examined in TDDSs for ketoprofen and clonidine. The dendrimer added did not show an enhancement effect on the TDDSs for the two drugs. To investigate the mechanism of the enhancement effect of a dendrimer on the tamsulosin TDDS, X-ray analyses were performed. With dendrimer addition, drug crystallization in PHA was promoted. The crystal in PHA had highly ordered and changed its space group. These findings are very important for exploiting high-performance PHA-based TDDSs.

AB - The possible application of polyhydroxyalkanoate (PHA) in transdermal drug delivery systems (TDDSs) for tamsulosin was previously reported. PHAs containing the drugs, ketoprofen, clonidine and tamsulosin showed good adhesiveness to the skin model used, that is, shed snake skin, and dispersed well all model drugs tested. The model drugs hardly permeated through snake skin in solution form. However, these drugs permeated well through snake skin from the PHA matrix. It was previously reported that the addition of a dendrimer, a polymeric permeation enhancer, is effective for the TDDS for tamsulosin to establish an effective clinical TDDS. The effect of dendrimer addition was examined in TDDSs for ketoprofen and clonidine. The dendrimer added did not show an enhancement effect on the TDDSs for the two drugs. To investigate the mechanism of the enhancement effect of a dendrimer on the tamsulosin TDDS, X-ray analyses were performed. With dendrimer addition, drug crystallization in PHA was promoted. The crystal in PHA had highly ordered and changed its space group. These findings are very important for exploiting high-performance PHA-based TDDSs.

KW - Dendrimer

KW - Enhancing effect

KW - Polyhydroxyalkanoate

KW - Transdermal drug delivery

KW - X-ray diffraction

UR - http://www.scopus.com/inward/record.url?scp=0346494969&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346494969&partnerID=8YFLogxK

U2 - 10.1263/jbb.96.537

DO - 10.1263/jbb.96.537

M3 - Article

C2 - 16233570

AN - SCOPUS:0346494969

VL - 96

SP - 537

EP - 540

JO - Journal of Bioscience and Bioengineering

JF - Journal of Bioscience and Bioengineering

SN - 1389-1723

IS - 6

ER -