Mechanism of Differences in Pathogenicity between Two Variants of a Laboratory Strain of Herpes Simplex Virus Type 1

Masao Yamada, Yujiro Arao, Fumio Uno, Shiro Nii

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The mechanisms responsible for the difference in neurovirulence to inbred mice between two variants of the Miyama strain of herpes simplex virus type 1 (HSV-1) were studied. After intraperitoneal (i.p.) inoculation, the +GC (LPV) variant reached the spinal cord and the brain, and caused death. Conversely, the — GCr variant lacked the ability to gain access to the central nervous system (CNS) after the same route of infection and failed to kill susceptible mice. The initial virus growth after i.p. inoculation, as indicated by the number of infective centers (ICs) produced by the peritoneal exudate cells (PECs), was compared be-tween these two variants. The virulent + GC (LPV) strain induced much more ICs than the attenuated — GCr variant. When the attenuated variant was preinoculated i.p. 24 hr before the challenge inoculation with the virulent variant by the same route, the production of ICs by the pathogenic variant was highly inhibited, and growth of this variant did not occur in the CNS. Thus, mice were protected from lethal infection by the virulent variant by preinoculation with the attenuated one. Moreover, the ability of mice to resist i.p. infection by HSV-1 was shown to be age-dependent.

Original languageEnglish
Pages (from-to)1259-1270
Number of pages12
JournalMICROBIOLOGY and IMMUNOLOGY
Volume30
Issue number12
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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