Mechanism of diethyldithiocarbamate-induced gastric ulder formation in the rat

Keiki Ogino, T. Hobara, T. Kawamoto, H. Kobayashi, S. Iwamoto, S. Oka, Y. Okazaki

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Diethyldithiocarbamate (DDC) was injected subcutaneously in the rat and the mechanism of gastric ulcer formation was investigated. DDC induced gastric ulcers in a dose- dependent manner. DDC significantly suppressed gastric mucosal copper-zinc superoxide dismutase (Cu, Zn-SOD) activity at 2hr. However, manganese-superoxide dismutase (Mn-SOD) activity was not changed. Gastric mucosal blood flow (GMBF) decreased to 52% of the control level ar 2 hr after administration of DDC and gradually increased to reach the control level by 7 hr. A shay rat preparation (4 hr) was used to study gastric secretion. DDC (200, 400 and 800 mg/kg inhibited acid secretion to about 80% of the control level. Histopathological examination of the gastric mucosa after administration of DDC revealed mucosal congestive findings from 1 hr to 3 hr. These data suggested that the mechanism of DDC-induced gastric ulcer formation may be attributable to a decreased level of GMBF and o2- production owing to decreased SOD activity.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalPharmacology and Toxicology
Volume66
Issue number2
Publication statusPublished - 1990
Externally publishedYes

Fingerprint

Ditiocarb
Rats
Stomach
Level control
Stomach Ulcer
Blood
Gastric Mucosa
Superoxide Dismutase
Zinc
Copper
Acids

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Ogino, K., Hobara, T., Kawamoto, T., Kobayashi, H., Iwamoto, S., Oka, S., & Okazaki, Y. (1990). Mechanism of diethyldithiocarbamate-induced gastric ulder formation in the rat. Pharmacology and Toxicology, 66(2), 133-137.

Mechanism of diethyldithiocarbamate-induced gastric ulder formation in the rat. / Ogino, Keiki; Hobara, T.; Kawamoto, T.; Kobayashi, H.; Iwamoto, S.; Oka, S.; Okazaki, Y.

In: Pharmacology and Toxicology, Vol. 66, No. 2, 1990, p. 133-137.

Research output: Contribution to journalArticle

Ogino, K, Hobara, T, Kawamoto, T, Kobayashi, H, Iwamoto, S, Oka, S & Okazaki, Y 1990, 'Mechanism of diethyldithiocarbamate-induced gastric ulder formation in the rat', Pharmacology and Toxicology, vol. 66, no. 2, pp. 133-137.
Ogino K, Hobara T, Kawamoto T, Kobayashi H, Iwamoto S, Oka S et al. Mechanism of diethyldithiocarbamate-induced gastric ulder formation in the rat. Pharmacology and Toxicology. 1990;66(2):133-137.
Ogino, Keiki ; Hobara, T. ; Kawamoto, T. ; Kobayashi, H. ; Iwamoto, S. ; Oka, S. ; Okazaki, Y. / Mechanism of diethyldithiocarbamate-induced gastric ulder formation in the rat. In: Pharmacology and Toxicology. 1990 ; Vol. 66, No. 2. pp. 133-137.
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