Mechanical stimulation induces CTGF expression in rat osteocytes

T. Yamashiro, T. Fukunaga, N. Kobashi, Hiroshi Kamioka, T. Nakanisni, Masaharu Takigawa, T. Takano-Yamamoto

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Connective tissue growth factor (CTGF), which is encoded by an immediate early gene and a member of the CCN family, has been shown to be expressed in osteoblasts, fibroblasts, and chondrocytes. Although CTGF is expressed in bone and cartilage tissues, we tested the hypothesis that CTGF is regulated in mechanotransduction. In the alveolar bone during experimental tooth movement, CTGF mRNA was expressed in osteoblasts and in osteocytes localized around the periodontal ligament under control conditions. Interestingly, 12 hrs after the start of experimental tooth movement, the expression of CTGF mRNA in osteocytes and osteoblasts became more intense around the periodontal ligament, and the intense expression of CTGF extended to osteocytes situated deep in alveolar bone matrix apart from periodontal ligament in both tension and compression sides. Our present findings indicate that CTGF could play a role in regulation of osteocyte function during the mechanical stimulation of bone.

Original languageEnglish
Pages (from-to)461-465
Number of pages5
JournalJournal of Dental Research
Volume80
Issue number2
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Connective Tissue Growth Factor
Osteocytes
Periodontal Ligament
Osteoblasts
Tooth Movement Techniques
Bone and Bones
Messenger RNA
Bone Matrix
Immediate-Early Genes
Chondrocytes
Cartilage
Fibroblasts

Keywords

  • Connective tissue growth factor (CTGF)
  • Mechanical stimulation
  • Osteoblast
  • Osteocyte
  • Tooth movement

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Yamashiro, T., Fukunaga, T., Kobashi, N., Kamioka, H., Nakanisni, T., Takigawa, M., & Takano-Yamamoto, T. (2001). Mechanical stimulation induces CTGF expression in rat osteocytes. Journal of Dental Research, 80(2), 461-465.

Mechanical stimulation induces CTGF expression in rat osteocytes. / Yamashiro, T.; Fukunaga, T.; Kobashi, N.; Kamioka, Hiroshi; Nakanisni, T.; Takigawa, Masaharu; Takano-Yamamoto, T.

In: Journal of Dental Research, Vol. 80, No. 2, 2001, p. 461-465.

Research output: Contribution to journalArticle

Yamashiro, T, Fukunaga, T, Kobashi, N, Kamioka, H, Nakanisni, T, Takigawa, M & Takano-Yamamoto, T 2001, 'Mechanical stimulation induces CTGF expression in rat osteocytes', Journal of Dental Research, vol. 80, no. 2, pp. 461-465.
Yamashiro T, Fukunaga T, Kobashi N, Kamioka H, Nakanisni T, Takigawa M et al. Mechanical stimulation induces CTGF expression in rat osteocytes. Journal of Dental Research. 2001;80(2):461-465.
Yamashiro, T. ; Fukunaga, T. ; Kobashi, N. ; Kamioka, Hiroshi ; Nakanisni, T. ; Takigawa, Masaharu ; Takano-Yamamoto, T. / Mechanical stimulation induces CTGF expression in rat osteocytes. In: Journal of Dental Research. 2001 ; Vol. 80, No. 2. pp. 461-465.
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