Mechanical stimulation induces CTGF expression in rat osteocytes

T. Yamashiro, T. Fukunaga, N. Kobashi, H. Kamioka, T. Nakanisni, M. Takigawa, T. Takano-Yamamoto

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)


Connective tissue growth factor (CTGF), which is encoded by an immediate early gene and a member of the CCN family, has been shown to be expressed in osteoblasts, fibroblasts, and chondrocytes. Although CTGF is expressed in bone and cartilage tissues, we tested the hypothesis that CTGF is regulated in mechanotransduction. In the alveolar bone during experimental tooth movement, CTGF mRNA was expressed in osteoblasts and in osteocytes localized around the periodontal ligament under control conditions. Interestingly, 12 hrs after the start of experimental tooth movement, the expression of CTGF mRNA in osteocytes and osteoblasts became more intense around the periodontal ligament, and the intense expression of CTGF extended to osteocytes situated deep in alveolar bone matrix apart from periodontal ligament in both tension and compression sides. Our present findings indicate that CTGF could play a role in regulation of osteocyte function during the mechanical stimulation of bone.

Original languageEnglish
Pages (from-to)461-465
Number of pages5
JournalJournal of dental research
Issue number2
Publication statusPublished - 2001
Externally publishedYes


  • Connective tissue growth factor (CTGF)
  • Mechanical stimulation
  • Osteoblast
  • Osteocyte
  • Tooth movement

ASJC Scopus subject areas

  • Dentistry(all)


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