Mechanical and biocompatibility properties of calcium phosphate bioceramics derived from salmon fish bone wastes

Merve Bas, Sibel Daglilar, Nilgun Kuskonmaz, Cevriye Kalkandelen, Gokce Erdemir, Serap E. Kuruca, Dilshat Tulyaganov, Tomohiko Yoshioka, Oguzhan Gunduz, Denisa Ficai, Anton Ficai

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13 Citations (Scopus)


Natural calcium phosphates derived from fish wastes are a promising material for biomedical application. However, their sintered ceramics are not fully characterized in terms of mechanical and biological properties. In this study, natural calcium phosphate was synthesized through a thermal calcination process from salmon fish bone wastes. The salmon-derived calcium phosphates (sCaP) were sintered at different temperatures to obtain natural calcium phosphate bioceramics and then were investigated in terms of their microstructure, mechanical properties and biocompatibility. In particular, this work is concerned with the effects of grain size on the relative density and microhardness of the sCaP bioceramics. Ca/P ratio of the sintered sCaP ranged from 1.73 to 1.52 when the sintering temperature was raised from 1000 to 1300 C. The crystal phase of all the sCaP bioceramics obtained was biphasic and composed of hydroxyapatite (HA) and tricalcium phosphate (TCP). The density and microhardness of the sCaP bioceramics increased in the temperature interval 1000–1100 C, while at temperatures higher than 1100 C, these properties were not significantly altered. The highest compressive strength of 116 MPa was recorded for the samples sintered at 1100 C. In vitro biocompatibility was also examined in the behavior of osteosarcoma (Saos-2) cells, indicating that the sCaP bioceramics had no cytotoxicity effect. Salmon-derived biphasic calcium phosphates (BCP) have the potential to contribute to the development of bone substituted materials.

Original languageEnglish
Article number8082
Pages (from-to)1-14
Number of pages14
JournalInternational journal of molecular sciences
Issue number21
Publication statusPublished - Nov 1 2020


  • Hydroxyapatite
  • Mechanical properties
  • Salmon fish bone
  • Sintering

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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