Measurement of Postmortem 1,5-anhydroglucitol in Vitreous Humor for Forensic Diagnosis

Tomoyo Takata, Yukie Yamasaki, Takashi Kitao, Satoru Miyaishi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In forensic diagnosis, postmortem blood glucose is known to be susceptible to change after death. However, the 1,5-anhydroglucitol (1,5-AG) concentrations in plasma and cerebrospinal fluid (CSF) reflect the mean blood glucose level for a short period of time. In this study, we compared the postmortem 1,5-AG concentrations in vitreous humor and CSF in 47 subjects to evaluate the utility of this concentration in the vitreous humor for forensic diagnosis. The postmortem 1,5-AG concentrations in vitreous humor (mean±SD: 20.2 ± 8.7 μg/mL) and CSF (16.8 ± 8.7 μg/mL) did not differ significantly and showed a strong correlation (r2 = 0.87, p < 0.01). These results suggest that the vitreous humor 1,5-AG concentration provides useful information on the antemortem blood glucose level, in addition to the HbA1c value and the CSF 1,5-AG concentration.

Original languageEnglish
Pages (from-to)150-153
Number of pages4
JournalJournal of Forensic Sciences
Volume61
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • 1,5-anhydroglucitol
  • Cerebrospinal fluid
  • Diabetes mellitus
  • Forensic science
  • Postmortem chemistry
  • Vitreous humor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Genetics

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