TY - JOUR
T1 - Measurement of Postmortem 1,5-anhydroglucitol in Vitreous Humor for Forensic Diagnosis
AU - Takata, Tomoyo
AU - Yamasaki, Yukie
AU - Kitao, Takashi
AU - Miyaishi, Satoru
N1 - Publisher Copyright:
© 2016 American Academy of Forensic Sciences.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - In forensic diagnosis, postmortem blood glucose is known to be susceptible to change after death. However, the 1,5-anhydroglucitol (1,5-AG) concentrations in plasma and cerebrospinal fluid (CSF) reflect the mean blood glucose level for a short period of time. In this study, we compared the postmortem 1,5-AG concentrations in vitreous humor and CSF in 47 subjects to evaluate the utility of this concentration in the vitreous humor for forensic diagnosis. The postmortem 1,5-AG concentrations in vitreous humor (mean±SD: 20.2 ± 8.7 μg/mL) and CSF (16.8 ± 8.7 μg/mL) did not differ significantly and showed a strong correlation (r2 = 0.87, p < 0.01). These results suggest that the vitreous humor 1,5-AG concentration provides useful information on the antemortem blood glucose level, in addition to the HbA1c value and the CSF 1,5-AG concentration.
AB - In forensic diagnosis, postmortem blood glucose is known to be susceptible to change after death. However, the 1,5-anhydroglucitol (1,5-AG) concentrations in plasma and cerebrospinal fluid (CSF) reflect the mean blood glucose level for a short period of time. In this study, we compared the postmortem 1,5-AG concentrations in vitreous humor and CSF in 47 subjects to evaluate the utility of this concentration in the vitreous humor for forensic diagnosis. The postmortem 1,5-AG concentrations in vitreous humor (mean±SD: 20.2 ± 8.7 μg/mL) and CSF (16.8 ± 8.7 μg/mL) did not differ significantly and showed a strong correlation (r2 = 0.87, p < 0.01). These results suggest that the vitreous humor 1,5-AG concentration provides useful information on the antemortem blood glucose level, in addition to the HbA1c value and the CSF 1,5-AG concentration.
KW - 1,5-anhydroglucitol
KW - Cerebrospinal fluid
KW - Diabetes mellitus
KW - Forensic science
KW - Postmortem chemistry
KW - Vitreous humor
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U2 - 10.1111/1556-4029.12963
DO - 10.1111/1556-4029.12963
M3 - Article
C2 - 26418332
AN - SCOPUS:84946067819
SN - 0022-1198
VL - 61
SP - 150
EP - 153
JO - Journal of Forensic Sciences
JF - Journal of Forensic Sciences
ER -
