Abstract
Objective: This study was designed to determine whether gamma cameras can be substituted for well-type scintillation counters in measuring blood radioactivity counts to be used as an input function for the quantitative measurement of cerebral blood flow (CBF). Methods: Twelve different aqueous 123I solutions were prepared by serial dilution of the original concentration of 281.9 kBq/ml, and the radioactivity count of each dilution was measured with a gamma camera with the collimator removed, and with a well-type scintillation counter. When measuring the radioactivity counts with a gamma camera, static images were acquired using a 128 x 128 matrix for 5 min, and the regions of interest with 14 x 14 pixels (21 mm x 21 mm) were defined. Results: There was a good correlation between the results obtained by these two procedures in the range of concentration between 0.008 kBq/ml and 281.9 kBq/ml (y = 4.245χ - 2.549, r = 1.0, n = 12, s.e.e. = 7.217 kcpm). There was good agreement between the CBF values (ml/100 g/min) obtained using the cross-calibration factor (CCF) and blood radioactivity counts measured with the two procedures (y = 0.990χ + 0.552, r = 0.990, n = 231, s.e.e. = 1.340 ml/100 g/min). Conclusion: The results suggest that gamma cameras can be substituted for well-type scintillation counters in the quantitative measurement of CBF, and make it unnecessary to measure CCF after routine calibration of a SPECT apparatus.
| Original language | English |
|---|---|
| Pages (from-to) | 191-195 |
| Number of pages | 5 |
| Journal | Journal of Nuclear Medicine Technology |
| Volume | 26 |
| Issue number | 3 |
| Publication status | Published - Sep 1998 |
| Externally published | Yes |
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Keywords
- Blood radioactivity
- Cerebral blood flow
- Cross-calibration factor
- Gamma camera
- Well-type scintillation counter
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Measurement of blood radioactivity for quantification of cerebral blood flow using a gamma camera. / Murase, Kenya; Fujioka, Hiroyoshi; Inoue, Takeshi; Ishimaru, Yoshihiro; Akamune, Akihisa; Yamamoto, Yuji; Ikezoe, Junpei.
In: Journal of Nuclear Medicine Technology, Vol. 26, No. 3, 09.1998, p. 191-195.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Measurement of blood radioactivity for quantification of cerebral blood flow using a gamma camera
AU - Murase, Kenya
AU - Fujioka, Hiroyoshi
AU - Inoue, Takeshi
AU - Ishimaru, Yoshihiro
AU - Akamune, Akihisa
AU - Yamamoto, Yuji
AU - Ikezoe, Junpei
PY - 1998/9
Y1 - 1998/9
N2 - Objective: This study was designed to determine whether gamma cameras can be substituted for well-type scintillation counters in measuring blood radioactivity counts to be used as an input function for the quantitative measurement of cerebral blood flow (CBF). Methods: Twelve different aqueous 123I solutions were prepared by serial dilution of the original concentration of 281.9 kBq/ml, and the radioactivity count of each dilution was measured with a gamma camera with the collimator removed, and with a well-type scintillation counter. When measuring the radioactivity counts with a gamma camera, static images were acquired using a 128 x 128 matrix for 5 min, and the regions of interest with 14 x 14 pixels (21 mm x 21 mm) were defined. Results: There was a good correlation between the results obtained by these two procedures in the range of concentration between 0.008 kBq/ml and 281.9 kBq/ml (y = 4.245χ - 2.549, r = 1.0, n = 12, s.e.e. = 7.217 kcpm). There was good agreement between the CBF values (ml/100 g/min) obtained using the cross-calibration factor (CCF) and blood radioactivity counts measured with the two procedures (y = 0.990χ + 0.552, r = 0.990, n = 231, s.e.e. = 1.340 ml/100 g/min). Conclusion: The results suggest that gamma cameras can be substituted for well-type scintillation counters in the quantitative measurement of CBF, and make it unnecessary to measure CCF after routine calibration of a SPECT apparatus.
AB - Objective: This study was designed to determine whether gamma cameras can be substituted for well-type scintillation counters in measuring blood radioactivity counts to be used as an input function for the quantitative measurement of cerebral blood flow (CBF). Methods: Twelve different aqueous 123I solutions were prepared by serial dilution of the original concentration of 281.9 kBq/ml, and the radioactivity count of each dilution was measured with a gamma camera with the collimator removed, and with a well-type scintillation counter. When measuring the radioactivity counts with a gamma camera, static images were acquired using a 128 x 128 matrix for 5 min, and the regions of interest with 14 x 14 pixels (21 mm x 21 mm) were defined. Results: There was a good correlation between the results obtained by these two procedures in the range of concentration between 0.008 kBq/ml and 281.9 kBq/ml (y = 4.245χ - 2.549, r = 1.0, n = 12, s.e.e. = 7.217 kcpm). There was good agreement between the CBF values (ml/100 g/min) obtained using the cross-calibration factor (CCF) and blood radioactivity counts measured with the two procedures (y = 0.990χ + 0.552, r = 0.990, n = 231, s.e.e. = 1.340 ml/100 g/min). Conclusion: The results suggest that gamma cameras can be substituted for well-type scintillation counters in the quantitative measurement of CBF, and make it unnecessary to measure CCF after routine calibration of a SPECT apparatus.
KW - Blood radioactivity
KW - Cerebral blood flow
KW - Cross-calibration factor
KW - Gamma camera
KW - Well-type scintillation counter
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UR - http://www.scopus.com/inward/citedby.url?scp=0031671637&partnerID=8YFLogxK
M3 - Article
C2 - 9755439
AN - SCOPUS:0031671637
VL - 26
SP - 191
EP - 195
JO - Journal of Nuclear Medicine Technology
JF - Journal of Nuclear Medicine Technology
SN - 0091-4916
IS - 3
ER -