Measurement of blood radioactivity for quantification of cerebral blood flow using a gamma camera

Kenya Murase, Hiroyoshi Fujioka, Takeshi Inoue, Yoshihiro Ishimaru, Akihisa Akamune, Yuji Yamamoto, Junpei Ikezoe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: This study was designed to determine whether gamma cameras can be substituted for well-type scintillation counters in measuring blood radioactivity counts to be used as an input function for the quantitative measurement of cerebral blood flow (CBF). Methods: Twelve different aqueous 123I solutions were prepared by serial dilution of the original concentration of 281.9 kBq/ml, and the radioactivity count of each dilution was measured with a gamma camera with the collimator removed, and with a well-type scintillation counter. When measuring the radioactivity counts with a gamma camera, static images were acquired using a 128 x 128 matrix for 5 min, and the regions of interest with 14 x 14 pixels (21 mm x 21 mm) were defined. Results: There was a good correlation between the results obtained by these two procedures in the range of concentration between 0.008 kBq/ml and 281.9 kBq/ml (y = 4.245χ - 2.549, r = 1.0, n = 12, s.e.e. = 7.217 kcpm). There was good agreement between the CBF values (ml/100 g/min) obtained using the cross-calibration factor (CCF) and blood radioactivity counts measured with the two procedures (y = 0.990χ + 0.552, r = 0.990, n = 231, s.e.e. = 1.340 ml/100 g/min). Conclusion: The results suggest that gamma cameras can be substituted for well-type scintillation counters in the quantitative measurement of CBF, and make it unnecessary to measure CCF after routine calibration of a SPECT apparatus.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalJournal of Nuclear Medicine Technology
Volume26
Issue number3
Publication statusPublished - Sep 1998
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Gamma Cameras
Scintillation Counting
Radioactivity
Calibration
Single-Photon Emission-Computed Tomography

Keywords

  • Blood radioactivity
  • Cerebral blood flow
  • Cross-calibration factor
  • Gamma camera
  • Well-type scintillation counter

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Murase, K., Fujioka, H., Inoue, T., Ishimaru, Y., Akamune, A., Yamamoto, Y., & Ikezoe, J. (1998). Measurement of blood radioactivity for quantification of cerebral blood flow using a gamma camera. Journal of Nuclear Medicine Technology, 26(3), 191-195.

Measurement of blood radioactivity for quantification of cerebral blood flow using a gamma camera. / Murase, Kenya; Fujioka, Hiroyoshi; Inoue, Takeshi; Ishimaru, Yoshihiro; Akamune, Akihisa; Yamamoto, Yuji; Ikezoe, Junpei.

In: Journal of Nuclear Medicine Technology, Vol. 26, No. 3, 09.1998, p. 191-195.

Research output: Contribution to journalArticle

Murase, K, Fujioka, H, Inoue, T, Ishimaru, Y, Akamune, A, Yamamoto, Y & Ikezoe, J 1998, 'Measurement of blood radioactivity for quantification of cerebral blood flow using a gamma camera', Journal of Nuclear Medicine Technology, vol. 26, no. 3, pp. 191-195.
Murase, Kenya ; Fujioka, Hiroyoshi ; Inoue, Takeshi ; Ishimaru, Yoshihiro ; Akamune, Akihisa ; Yamamoto, Yuji ; Ikezoe, Junpei. / Measurement of blood radioactivity for quantification of cerebral blood flow using a gamma camera. In: Journal of Nuclear Medicine Technology. 1998 ; Vol. 26, No. 3. pp. 191-195.
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