MCP-1 mRNA expression in basal keratinocytes of psoriatic lesions

Reinhard Gillitzer, Klaus Wolff, Dan Tong, Christoph Müller, Teizo Yoshimura, Albert A. Hartmann, Georg Stingl, Rudolf Berger

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

In addition to hyperproliferation of keratinocytes, psoriasis is characterized by pronounced leukocytic infiltration. In contrast to the epidermal localization of neutrophils and T lymphocytes, macrophages are almost exclusively restricted to the dermal compartment. By immunohistologic analysis, these dermal macrophages were mainly encountered in the papillary dermis and arranged along the rete ridges in close proximity to proliferating keratinocytes. Monocyte chemoattractant protein (MCP-1) anti-sense RNA probes yielded abundant signals over the proliferating basal keratinocytes of the tips of the rete ridges, and, to a lesser extent, in cells in the papillae. Thus, the strongest MCP-1 message in psoriatic lesions is found above the dermal-epidermal junction and this may explain the characteristic sub-basal distribution of dermal macrophages. These results suggest that MCP-1 is important in regulating the interaction between proliferating keratinocytes and dermal macrophages in psoriasis pathogenesis.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalJournal of Investigative Dermatology
Volume101
Issue number2
Publication statusPublished - Aug 1993
Externally publishedYes

Fingerprint

Macrophages
Keratinocytes
Messenger RNA
Skin
Monocyte Chemoattractant Proteins
Psoriasis
RNA Probes
Antisense RNA
T-cells
Infiltration
Chemokine CCL2
Dermis
Neutrophils
T-Lymphocytes

Keywords

  • in situ hybridization
  • monocyte-macrophage chemotaxis

ASJC Scopus subject areas

  • Dermatology

Cite this

Gillitzer, R., Wolff, K., Tong, D., Müller, C., Yoshimura, T., Hartmann, A. A., ... Berger, R. (1993). MCP-1 mRNA expression in basal keratinocytes of psoriatic lesions. Journal of Investigative Dermatology, 101(2), 127-131.

MCP-1 mRNA expression in basal keratinocytes of psoriatic lesions. / Gillitzer, Reinhard; Wolff, Klaus; Tong, Dan; Müller, Christoph; Yoshimura, Teizo; Hartmann, Albert A.; Stingl, Georg; Berger, Rudolf.

In: Journal of Investigative Dermatology, Vol. 101, No. 2, 08.1993, p. 127-131.

Research output: Contribution to journalArticle

Gillitzer, R, Wolff, K, Tong, D, Müller, C, Yoshimura, T, Hartmann, AA, Stingl, G & Berger, R 1993, 'MCP-1 mRNA expression in basal keratinocytes of psoriatic lesions', Journal of Investigative Dermatology, vol. 101, no. 2, pp. 127-131.
Gillitzer R, Wolff K, Tong D, Müller C, Yoshimura T, Hartmann AA et al. MCP-1 mRNA expression in basal keratinocytes of psoriatic lesions. Journal of Investigative Dermatology. 1993 Aug;101(2):127-131.
Gillitzer, Reinhard ; Wolff, Klaus ; Tong, Dan ; Müller, Christoph ; Yoshimura, Teizo ; Hartmann, Albert A. ; Stingl, Georg ; Berger, Rudolf. / MCP-1 mRNA expression in basal keratinocytes of psoriatic lesions. In: Journal of Investigative Dermatology. 1993 ; Vol. 101, No. 2. pp. 127-131.
@article{7d0cbbb2b7894a9f8f81d961fa204902,
title = "MCP-1 mRNA expression in basal keratinocytes of psoriatic lesions",
abstract = "In addition to hyperproliferation of keratinocytes, psoriasis is characterized by pronounced leukocytic infiltration. In contrast to the epidermal localization of neutrophils and T lymphocytes, macrophages are almost exclusively restricted to the dermal compartment. By immunohistologic analysis, these dermal macrophages were mainly encountered in the papillary dermis and arranged along the rete ridges in close proximity to proliferating keratinocytes. Monocyte chemoattractant protein (MCP-1) anti-sense RNA probes yielded abundant signals over the proliferating basal keratinocytes of the tips of the rete ridges, and, to a lesser extent, in cells in the papillae. Thus, the strongest MCP-1 message in psoriatic lesions is found above the dermal-epidermal junction and this may explain the characteristic sub-basal distribution of dermal macrophages. These results suggest that MCP-1 is important in regulating the interaction between proliferating keratinocytes and dermal macrophages in psoriasis pathogenesis.",
keywords = "in situ hybridization, monocyte-macrophage chemotaxis",
author = "Reinhard Gillitzer and Klaus Wolff and Dan Tong and Christoph M{\"u}ller and Teizo Yoshimura and Hartmann, {Albert A.} and Georg Stingl and Rudolf Berger",
year = "1993",
month = "8",
language = "English",
volume = "101",
pages = "127--131",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - MCP-1 mRNA expression in basal keratinocytes of psoriatic lesions

AU - Gillitzer, Reinhard

AU - Wolff, Klaus

AU - Tong, Dan

AU - Müller, Christoph

AU - Yoshimura, Teizo

AU - Hartmann, Albert A.

AU - Stingl, Georg

AU - Berger, Rudolf

PY - 1993/8

Y1 - 1993/8

N2 - In addition to hyperproliferation of keratinocytes, psoriasis is characterized by pronounced leukocytic infiltration. In contrast to the epidermal localization of neutrophils and T lymphocytes, macrophages are almost exclusively restricted to the dermal compartment. By immunohistologic analysis, these dermal macrophages were mainly encountered in the papillary dermis and arranged along the rete ridges in close proximity to proliferating keratinocytes. Monocyte chemoattractant protein (MCP-1) anti-sense RNA probes yielded abundant signals over the proliferating basal keratinocytes of the tips of the rete ridges, and, to a lesser extent, in cells in the papillae. Thus, the strongest MCP-1 message in psoriatic lesions is found above the dermal-epidermal junction and this may explain the characteristic sub-basal distribution of dermal macrophages. These results suggest that MCP-1 is important in regulating the interaction between proliferating keratinocytes and dermal macrophages in psoriasis pathogenesis.

AB - In addition to hyperproliferation of keratinocytes, psoriasis is characterized by pronounced leukocytic infiltration. In contrast to the epidermal localization of neutrophils and T lymphocytes, macrophages are almost exclusively restricted to the dermal compartment. By immunohistologic analysis, these dermal macrophages were mainly encountered in the papillary dermis and arranged along the rete ridges in close proximity to proliferating keratinocytes. Monocyte chemoattractant protein (MCP-1) anti-sense RNA probes yielded abundant signals over the proliferating basal keratinocytes of the tips of the rete ridges, and, to a lesser extent, in cells in the papillae. Thus, the strongest MCP-1 message in psoriatic lesions is found above the dermal-epidermal junction and this may explain the characteristic sub-basal distribution of dermal macrophages. These results suggest that MCP-1 is important in regulating the interaction between proliferating keratinocytes and dermal macrophages in psoriasis pathogenesis.

KW - in situ hybridization

KW - monocyte-macrophage chemotaxis

UR - http://www.scopus.com/inward/record.url?scp=0027305254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027305254&partnerID=8YFLogxK

M3 - Article

VL - 101

SP - 127

EP - 131

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 2

ER -