Mast Cells in Osteoarthritic and Rheumatoid Arthritic Synovial Tissues of the Human Knee

Jian Pu, Keiichiro Nishida, Hajime Inoue, Hiroshi Asahara, Aiji Ohtsuka, Takuro Murakami

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The distribution and density of mast cells in the normal and diseased synovial membranes were investigated. The mast cell count (MCC) in the osteoarthritic (OA) synovium (36.9 ± 26.9 cells/mm2) was significantly higher than that in the rheumatoid arthritic (RA) synovium (18 ± 12.3 cells/mm2). There was a marked positive correlation between the MCC and the volume of joint fluid in OA (r = 0.544). There was a marked negative correlation between the MCC and the volume of joint fluid in RA (r = -0.478). The synovial inflammatory score had a poor correlation with the MCC in OA (r = 0.377) and RA (r = 0.305). No correlation was noted between MCC and age, sex, roentgenographic grades, disease duration, C-reactive protein or leucocyte number in synovial fluid. Our data suggests, thus, that mast cells could be involved in the pathogenesis of inflammatory diseases of the synovium, especially in the mechanism of hydroarthrosis.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalActa medica Okayama
Volume52
Issue number1
Publication statusPublished - Feb 1 1998

Keywords

  • Hydroarthrosis
  • Mast cell count
  • Osteoarthritis
  • Rheumatoid arthritis
  • Synovial membrane

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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