Mast cell degranulating peptide forms voltage gated and cation-selective channels in lipid bilayers

Toru Ide, Takahisa Taguchi, Takuma Morita, Masayuki Sato, Kazuhiro Ikenaka, Saburo Aimoto, Tetsuro Kondo, Hironobu Hojo, Michiki Kasai, Katsuhiko Mikoshiba

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Mast cell degranulating peptide, a toxin of bee venom, is a polypeptide composed of 22 amino acids. Exposure of the asolectin bilayer to the peptide results in the formation of channels that are more permeable to K+ than Cl-. These channels are activated when the voltage of the cis side, to which the peptide is added, is made positive.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume163
Issue number1
DOIs
Publication statusPublished - Aug 30 1989
Externally publishedYes

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Lipid bilayers
Lipid Bilayers
Cations
Peptides
Electric potential
Bee Venoms
Amino Acids
mast cell degranulating peptide

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Mast cell degranulating peptide forms voltage gated and cation-selective channels in lipid bilayers. / Ide, Toru; Taguchi, Takahisa; Morita, Takuma; Sato, Masayuki; Ikenaka, Kazuhiro; Aimoto, Saburo; Kondo, Tetsuro; Hojo, Hironobu; Kasai, Michiki; Mikoshiba, Katsuhiko.

In: Biochemical and Biophysical Research Communications, Vol. 163, No. 1, 30.08.1989, p. 155-160.

Research output: Contribution to journalArticle

Ide, T, Taguchi, T, Morita, T, Sato, M, Ikenaka, K, Aimoto, S, Kondo, T, Hojo, H, Kasai, M & Mikoshiba, K 1989, 'Mast cell degranulating peptide forms voltage gated and cation-selective channels in lipid bilayers', Biochemical and Biophysical Research Communications, vol. 163, no. 1, pp. 155-160. https://doi.org/10.1016/0006-291X(89)92113-X
Ide, Toru ; Taguchi, Takahisa ; Morita, Takuma ; Sato, Masayuki ; Ikenaka, Kazuhiro ; Aimoto, Saburo ; Kondo, Tetsuro ; Hojo, Hironobu ; Kasai, Michiki ; Mikoshiba, Katsuhiko. / Mast cell degranulating peptide forms voltage gated and cation-selective channels in lipid bilayers. In: Biochemical and Biophysical Research Communications. 1989 ; Vol. 163, No. 1. pp. 155-160.
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AU - Kondo, Tetsuro

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