Massive Bleeding due to Hyperfibrinolysis during Living-related Liver Transplantation for Terminal Liver Cirrhosis; Report of Two Cases

Ryuji Kaku, Masaki Matsumi, Masako Ichiyama, Hidetoshi Kajihara, Hiromi Fujii, Ichirou Ohashi, Satoshi Mizobuchi, Kiyoshi Morita

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Abstract

We reported two cases of massive bleeding due to critical hyperfibrinolysis during living-related liver transplantation (LRLT) for end stage liver cirrhosis. The total volume of bleeding amounted to 57930 ml with the case 1, and amounted to 55980 ml with the case 2. TEG was useful for diagnosis of the hyperfibrinolysis. We administrated large amounts of FFPs, MAPs, PLTs, and gabexate mesilate. By rapid transfusion, we could manage to finish the procedures without hypotension, and complications were not observed at the early postoperative stage. We thought that the cause of the hyperfibrinolysis is the increasing blood tissue plasminogen activator (t-PA) due to long anhepatic stage and small graft size. During anesthesia, since the functional start of a transplant liver is indispensable to it, in order to support a transplant liver for an improvement of hyperfibrinolysis, it is important to keep the homeostasis, such as body temperature, blood pressure.

Original languageEnglish
Pages (from-to)1195-1199
Number of pages5
JournalJapanese Journal of Anesthesiology
Volume52
Issue number11
Publication statusPublished - Nov 2003

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Keywords

  • Hyperfibrinolysis
  • Liver cirrhosis
  • Living-related liver transplantation
  • Massive bleeding

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Kaku, R., Matsumi, M., Ichiyama, M., Kajihara, H., Fujii, H., Ohashi, I., Mizobuchi, S., & Morita, K. (2003). Massive Bleeding due to Hyperfibrinolysis during Living-related Liver Transplantation for Terminal Liver Cirrhosis; Report of Two Cases. Japanese Journal of Anesthesiology, 52(11), 1195-1199.