Abstract
Objective: Even though diabetes patients exhibit an increased oxidative stress, its correlation with diabetic nephropathy is not fully understood. The purpose of this study was to determine whether lipid peroxidation marker correlates well with eGFR and UACR in type 2 diabetes mellitus patients. Methods: We collected urine and serum samples of Indonesian type 2 diabetes mellitus outpatients with normo- and microalbuminuria at a Local Government Clinic (from ages: 39-74 years). Urinary 8-iso-PGF2α was measured by ELISA, the serum malondialdehyde by TBARS assay, and urinary albumin by BCG albumin assay. eGFR was calculated using the corrected-Cockcroft-Gault (CG), MDRD, and CKD-EPI equation. Other necessary data were obtained through questionnaires. Results: The results showed that the increasing level of malondialdehyde was mildly correlated with the decline in eGFR (MDRD). In contrary, there was a significant positive correlation between 8-iso-PGF2α concentration and eGFR based on the corrected-CG, MDRD study, and CKD-EPI equation (r=0.457, p2α together with fasting plasma glucose was the most predictive factor for the high 2-quantile eGFR (adjusted OR 1.001, (95% CI, 1.000-1.001)). However, there was no significant correlation between UACR with malondialdehyde (r=0.268, p=0.050) and 8-iso-PGF2α(r=-0.030, p=0.808). UACR itself was inversely correlated with eGFR based on the corrected-CG, the MDRD, and CKD-EPI (r=-0.232, p2α and malondialdehyde in type 2 diabetes mellitus patients may play a role in the pathophysiologic significance of diabetic nephropathy, even while considering the effect of potential confounders.
| Original language | English |
|---|---|
| Pages (from-to) | 193-200 |
| Number of pages | 8 |
| Journal | Diabetes Research and Clinical Practice |
| Volume | 108 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 1 2015 |
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Keywords
- 8-iso-PGF
- Diabetes mellitus
- Estimated glomerular filtration rate
- Urine albumin to creatinine ratio
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Internal Medicine
- Endocrinology
- Medicine(all)
Cite this
Marker of lipid peroxidation related to diabetic nephropathy in Indonesian type 2 diabetes mellitus patients. / Sauriasari, R.; Andrajati, R.; Azizahwati; Dharmeizar; Saputri, D. A.; Muris, R. U.; Manfaatun, A.; Amanda, O. F.; Setiawan, H.; Sakano, N.; Wang, D. H.; Ogino, Keiki.
In: Diabetes Research and Clinical Practice, Vol. 108, No. 1, 01.04.2015, p. 193-200.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Marker of lipid peroxidation related to diabetic nephropathy in Indonesian type 2 diabetes mellitus patients
AU - Sauriasari, R.
AU - Andrajati, R.
AU - Azizahwati,
AU - Dharmeizar,
AU - Saputri, D. A.
AU - Muris, R. U.
AU - Manfaatun, A.
AU - Amanda, O. F.
AU - Setiawan, H.
AU - Sakano, N.
AU - Wang, D. H.
AU - Ogino, Keiki
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Objective: Even though diabetes patients exhibit an increased oxidative stress, its correlation with diabetic nephropathy is not fully understood. The purpose of this study was to determine whether lipid peroxidation marker correlates well with eGFR and UACR in type 2 diabetes mellitus patients. Methods: We collected urine and serum samples of Indonesian type 2 diabetes mellitus outpatients with normo- and microalbuminuria at a Local Government Clinic (from ages: 39-74 years). Urinary 8-iso-PGF2α was measured by ELISA, the serum malondialdehyde by TBARS assay, and urinary albumin by BCG albumin assay. eGFR was calculated using the corrected-Cockcroft-Gault (CG), MDRD, and CKD-EPI equation. Other necessary data were obtained through questionnaires. Results: The results showed that the increasing level of malondialdehyde was mildly correlated with the decline in eGFR (MDRD). In contrary, there was a significant positive correlation between 8-iso-PGF2α concentration and eGFR based on the corrected-CG, MDRD study, and CKD-EPI equation (r=0.457, p2α together with fasting plasma glucose was the most predictive factor for the high 2-quantile eGFR (adjusted OR 1.001, (95% CI, 1.000-1.001)). However, there was no significant correlation between UACR with malondialdehyde (r=0.268, p=0.050) and 8-iso-PGF2α(r=-0.030, p=0.808). UACR itself was inversely correlated with eGFR based on the corrected-CG, the MDRD, and CKD-EPI (r=-0.232, p2α and malondialdehyde in type 2 diabetes mellitus patients may play a role in the pathophysiologic significance of diabetic nephropathy, even while considering the effect of potential confounders.
AB - Objective: Even though diabetes patients exhibit an increased oxidative stress, its correlation with diabetic nephropathy is not fully understood. The purpose of this study was to determine whether lipid peroxidation marker correlates well with eGFR and UACR in type 2 diabetes mellitus patients. Methods: We collected urine and serum samples of Indonesian type 2 diabetes mellitus outpatients with normo- and microalbuminuria at a Local Government Clinic (from ages: 39-74 years). Urinary 8-iso-PGF2α was measured by ELISA, the serum malondialdehyde by TBARS assay, and urinary albumin by BCG albumin assay. eGFR was calculated using the corrected-Cockcroft-Gault (CG), MDRD, and CKD-EPI equation. Other necessary data were obtained through questionnaires. Results: The results showed that the increasing level of malondialdehyde was mildly correlated with the decline in eGFR (MDRD). In contrary, there was a significant positive correlation between 8-iso-PGF2α concentration and eGFR based on the corrected-CG, MDRD study, and CKD-EPI equation (r=0.457, p2α together with fasting plasma glucose was the most predictive factor for the high 2-quantile eGFR (adjusted OR 1.001, (95% CI, 1.000-1.001)). However, there was no significant correlation between UACR with malondialdehyde (r=0.268, p=0.050) and 8-iso-PGF2α(r=-0.030, p=0.808). UACR itself was inversely correlated with eGFR based on the corrected-CG, the MDRD, and CKD-EPI (r=-0.232, p2α and malondialdehyde in type 2 diabetes mellitus patients may play a role in the pathophysiologic significance of diabetic nephropathy, even while considering the effect of potential confounders.
KW - 8-iso-PGF
KW - Diabetes mellitus
KW - Estimated glomerular filtration rate
KW - Urine albumin to creatinine ratio
UR - http://www.scopus.com/inward/record.url?scp=84938484129&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938484129&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2014.12.016
DO - 10.1016/j.diabres.2014.12.016
M3 - Article
C2 - 25726335
AN - SCOPUS:84938484129
VL - 108
SP - 193
EP - 200
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
IS - 1
ER -