Marine cytotoxic macrolides haterumalides and biselides, and related natural products

Hideo Kigoshi, Ichiro Hayakawa

Research output: Contribution to journalArticle

22 Citations (Scopus)


Marine animals and plants are rich sources of bioactive natural products. Haterumalides and biselides, isolated from Okinawan marine animals, are 14-membered macrolides with strong cytotoxicity against human cancer cell lines. This review highlights the isolation, structures, bioactivities, and total synthesis of haterumalides, biselides, and related natural products.

Original languageEnglish
Pages (from-to)254-264
Number of pages11
JournalChemical Record
Issue number4
Publication statusPublished - Oct 4 2007
Externally publishedYes



  • Biselides
  • Haterumalides
  • Human cancer cell lines
  • Marine cytotoxic macrolide

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Chemical Engineering(all)
  • Materials Chemistry

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