Marginal zone lymphoma and lung adenocarcinoma with an EGFR Exon 19 E746-S752del mutation in a patient with IgG4-related disease

Sachi Okawa, Kanmei Rai, Nobuharu Fujii, Yuka Gion, Kiichiro Ninomiya, Yuka Kato, Akihiko Taniguchi, Toshio Kubo, Eiki Ichihara, Kadoaki Ohashi, Nobuaki Miyahara, Katsuyuki Hotta, Masahiro Tabata, Yoshinobu Maeda, Katsuyuki Kiura

Research output: Contribution to journalArticlepeer-review

Abstract

A 68-year-old man presented with a solid mass at the left renal pelvis and ureter with multiple systemic lymphadenopathies and a mass with a cavity in the right lower lobe of the lung. While a transbronchial lung biopsy revealed no malignancy, a biopsy of the renal pelvis showed marginal zone lymphoma with polyclonal IgG4-positive cells. The serum IgG4 level and presence of a bilateral orbital mass suggested Mikulicz disease. The lesions shrank following the administration of steroids. A rebiopsy confirmed lung adenocarcinoma, and its background showed IgG4-positive cells a year later. IgG4-related diseases require careful follow-up because they can be complicated by malignancy.

Original languageEnglish
Pages (from-to)2831-2837
Number of pages7
JournalInternal Medicine
Volume60
Issue number17
DOIs
Publication statusPublished - 2021

Keywords

  • EGFR
  • IgG4-related disease
  • Marginal zone lymphoma
  • Osimertinib

ASJC Scopus subject areas

  • Internal Medicine

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