Marginal zone lymphoma and lung adenocarcinoma with an EGFR Exon 19 E746-S752del mutation in a patient with IgG4-related disease

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Abstract

A 68-year-old man presented with a solid mass at the left renal pelvis and ureter with multiple systemic lymphadenopathies and a mass with a cavity in the right lower lobe of the lung. While a transbronchial lung biopsy revealed no malignancy, a biopsy of the renal pelvis showed marginal zone lymphoma with polyclonal IgG4-positive cells. The serum IgG4 level and presence of a bilateral orbital mass suggested Mikulicz disease. The lesions shrank following the administration of steroids. A rebiopsy confirmed lung adenocarcinoma, and its background showed IgG4-positive cells a year later. IgG4-related diseases require careful follow-up because they can be complicated by malignancy.

Original languageEnglish
Pages (from-to)2831-2837
Number of pages7
JournalInternal Medicine
Volume60
Issue number17
DOIs
Publication statusPublished - 2021

Keywords

  • EGFR
  • IgG4-related disease
  • Marginal zone lymphoma
  • Osimertinib

ASJC Scopus subject areas

  • Internal Medicine

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