Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.

Takaaki Kubota; Yuichiro Ishiguro; Azusa Takahashi-Nakaguchi; Jane Fromont; Tohru Gonoi; Jun'Ichi Kobayashi

doi:10.1016/j.bmcl.2012.10.109

Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.

Takaaki Kubota, Yuichiro Ishiguro, Azusa Takahashi-Nakaguchi, Jane Fromont, Tohru Gonoi, Jun'Ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data. Manzamenones L-N (1-3) were new dimeric fatty-acid derivatives consisting of a tetrahydroindenone with three carboxy groups and two hexadecanyl chains. Manzamenones M (2) and N (3) showed antimicrobial activity against several bacteria and fungi.

Original language	English
Pages (from-to)	244-247
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2012.10.109
Publication status	Published - Jan 1 2013
Externally published	Yes

Keywords

Antimicrobial activity
Dimeric fatty-acid derivative
Manzamenones L-N
Marine sponge
Plakortis sp.

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2012.10.109

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title = "Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.",

abstract = "Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data. Manzamenones L-N (1-3) were new dimeric fatty-acid derivatives consisting of a tetrahydroindenone with three carboxy groups and two hexadecanyl chains. Manzamenones M (2) and N (3) showed antimicrobial activity against several bacteria and fungi.",

keywords = "Antimicrobial activity, Dimeric fatty-acid derivative, Manzamenones L-N, Marine sponge, Plakortis sp.",

author = "Takaaki Kubota and Yuichiro Ishiguro and Azusa Takahashi-Nakaguchi and Jane Fromont and Tohru Gonoi and Jun'Ichi Kobayashi",

note = "Funding Information: We thank Mr. Z. Nagahama for his help with sponge collection, and Ms. S. Oka, Instrumental Analysis Division, Equipment Management Center, Creative Reseach Institution, Hokkaido University, for measurements of ESIMS. This work was supported by the Akiyama Life Sience Foundation, the Suhara Memorial Foundation, and Grant-in-Aid for Scientific Research on Innovative Areas (Biosynthetic Machinery) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. ",

year = "2013",

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doi = "10.1016/j.bmcl.2012.10.109",

language = "English",

volume = "23",

pages = "244--247",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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T1 - Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.

AU - Kubota, Takaaki

AU - Ishiguro, Yuichiro

AU - Takahashi-Nakaguchi, Azusa

AU - Fromont, Jane

AU - Gonoi, Tohru

AU - Kobayashi, Jun'Ichi

N1 - Funding Information: We thank Mr. Z. Nagahama for his help with sponge collection, and Ms. S. Oka, Instrumental Analysis Division, Equipment Management Center, Creative Reseach Institution, Hokkaido University, for measurements of ESIMS. This work was supported by the Akiyama Life Sience Foundation, the Suhara Memorial Foundation, and Grant-in-Aid for Scientific Research on Innovative Areas (Biosynthetic Machinery) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data. Manzamenones L-N (1-3) were new dimeric fatty-acid derivatives consisting of a tetrahydroindenone with three carboxy groups and two hexadecanyl chains. Manzamenones M (2) and N (3) showed antimicrobial activity against several bacteria and fungi.

AB - Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data. Manzamenones L-N (1-3) were new dimeric fatty-acid derivatives consisting of a tetrahydroindenone with three carboxy groups and two hexadecanyl chains. Manzamenones M (2) and N (3) showed antimicrobial activity against several bacteria and fungi.

KW - Antimicrobial activity

KW - Dimeric fatty-acid derivative

KW - Manzamenones L-N

KW - Marine sponge

KW - Plakortis sp.

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JO - Bioorganic and Medicinal Chemistry Letters

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Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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