Manifestation of rheumatoid arthritis after transsphenoidal surgery in a patient with acromegaly

Tomoko Miyoshi, Fumio Otsuka, Tomoko Kawabata, Kenichi Inagaki, Tomoyuki Mukai, Masanori Kawashima, Toshio Ogura, Masahiro Yamamura, Tetsuro Sei, Hirofumi Makino

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Acromegalic arthropathy is one of the most frequent manifestations occurring in acromegaly patients. In contrast, rheumatoid arthritis (RA) is a rare clinical complication in acromegaly patients. Here, we report a 70-year-old Japanese woman with acromegaly, who complained of bilateral finger stiffness and polyarthralgia two months after transsphenoidal surgery of a growth hormone (GH)-secreting pituitary adenoma. Postoperative levels of serum GH and insulin-like growth factor-1 (IGF-1) were markedly decreased without any secretory deficiency of other anterior pituitary hormones. Hand X-ray did not show typical RA changes; however, erosive changes in carpal bones were clearly detected by magnetic resonance imaging with gadolinium enhancement. Based on the levels of serological markers in the patient following surgery including C-reactive protein, rheumatoid factor and matrix metalloproteinase-3, anti-rheumatic therapy was subsequently commenced. Regardless of the levels of GH and IGF-1, acromegaly patients frequently complain about joint-related symptoms even after remission. Therefore, careful observation of bone erosive changes and immunological activity in acromegaly patients is required when joint-related symptoms persist.

Original languageEnglish
Pages (from-to)621-625
Number of pages5
JournalEndocrine Journal
Volume53
Issue number5
DOIs
Publication statusPublished - 2006

Fingerprint

Acromegaly
Rheumatoid Arthritis
Somatomedins
Growth Hormone
Joints
Growth Hormone-Secreting Pituitary Adenoma
Anterior Pituitary Hormones
Carpal Bones
Matrix Metalloproteinase 3
Joint Diseases
Rheumatoid Factor
Gadolinium
Arthralgia
C-Reactive Protein
Fingers
Hand
Magnetic Resonance Imaging
Observation
X-Rays
Bone and Bones

Keywords

  • Acromegaly
  • Arthropathy
  • Growth hormone
  • Pituitary adenoma
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Endocrinology

Cite this

Manifestation of rheumatoid arthritis after transsphenoidal surgery in a patient with acromegaly. / Miyoshi, Tomoko; Otsuka, Fumio; Kawabata, Tomoko; Inagaki, Kenichi; Mukai, Tomoyuki; Kawashima, Masanori; Ogura, Toshio; Yamamura, Masahiro; Sei, Tetsuro; Makino, Hirofumi.

In: Endocrine Journal, Vol. 53, No. 5, 2006, p. 621-625.

Research output: Contribution to journalArticle

Miyoshi, Tomoko ; Otsuka, Fumio ; Kawabata, Tomoko ; Inagaki, Kenichi ; Mukai, Tomoyuki ; Kawashima, Masanori ; Ogura, Toshio ; Yamamura, Masahiro ; Sei, Tetsuro ; Makino, Hirofumi. / Manifestation of rheumatoid arthritis after transsphenoidal surgery in a patient with acromegaly. In: Endocrine Journal. 2006 ; Vol. 53, No. 5. pp. 621-625.
@article{08ec0f45558a47e88db1aa063d0f1df8,
title = "Manifestation of rheumatoid arthritis after transsphenoidal surgery in a patient with acromegaly",
abstract = "Acromegalic arthropathy is one of the most frequent manifestations occurring in acromegaly patients. In contrast, rheumatoid arthritis (RA) is a rare clinical complication in acromegaly patients. Here, we report a 70-year-old Japanese woman with acromegaly, who complained of bilateral finger stiffness and polyarthralgia two months after transsphenoidal surgery of a growth hormone (GH)-secreting pituitary adenoma. Postoperative levels of serum GH and insulin-like growth factor-1 (IGF-1) were markedly decreased without any secretory deficiency of other anterior pituitary hormones. Hand X-ray did not show typical RA changes; however, erosive changes in carpal bones were clearly detected by magnetic resonance imaging with gadolinium enhancement. Based on the levels of serological markers in the patient following surgery including C-reactive protein, rheumatoid factor and matrix metalloproteinase-3, anti-rheumatic therapy was subsequently commenced. Regardless of the levels of GH and IGF-1, acromegaly patients frequently complain about joint-related symptoms even after remission. Therefore, careful observation of bone erosive changes and immunological activity in acromegaly patients is required when joint-related symptoms persist.",
keywords = "Acromegaly, Arthropathy, Growth hormone, Pituitary adenoma, Rheumatoid arthritis",
author = "Tomoko Miyoshi and Fumio Otsuka and Tomoko Kawabata and Kenichi Inagaki and Tomoyuki Mukai and Masanori Kawashima and Toshio Ogura and Masahiro Yamamura and Tetsuro Sei and Hirofumi Makino",
year = "2006",
doi = "10.1507/endocrj.K06-043",
language = "English",
volume = "53",
pages = "621--625",
journal = "Endocrine Journal",
issn = "0918-8959",
publisher = "Japan Endocrine Society",
number = "5",

}

TY - JOUR

T1 - Manifestation of rheumatoid arthritis after transsphenoidal surgery in a patient with acromegaly

AU - Miyoshi, Tomoko

AU - Otsuka, Fumio

AU - Kawabata, Tomoko

AU - Inagaki, Kenichi

AU - Mukai, Tomoyuki

AU - Kawashima, Masanori

AU - Ogura, Toshio

AU - Yamamura, Masahiro

AU - Sei, Tetsuro

AU - Makino, Hirofumi

PY - 2006

Y1 - 2006

N2 - Acromegalic arthropathy is one of the most frequent manifestations occurring in acromegaly patients. In contrast, rheumatoid arthritis (RA) is a rare clinical complication in acromegaly patients. Here, we report a 70-year-old Japanese woman with acromegaly, who complained of bilateral finger stiffness and polyarthralgia two months after transsphenoidal surgery of a growth hormone (GH)-secreting pituitary adenoma. Postoperative levels of serum GH and insulin-like growth factor-1 (IGF-1) were markedly decreased without any secretory deficiency of other anterior pituitary hormones. Hand X-ray did not show typical RA changes; however, erosive changes in carpal bones were clearly detected by magnetic resonance imaging with gadolinium enhancement. Based on the levels of serological markers in the patient following surgery including C-reactive protein, rheumatoid factor and matrix metalloproteinase-3, anti-rheumatic therapy was subsequently commenced. Regardless of the levels of GH and IGF-1, acromegaly patients frequently complain about joint-related symptoms even after remission. Therefore, careful observation of bone erosive changes and immunological activity in acromegaly patients is required when joint-related symptoms persist.

AB - Acromegalic arthropathy is one of the most frequent manifestations occurring in acromegaly patients. In contrast, rheumatoid arthritis (RA) is a rare clinical complication in acromegaly patients. Here, we report a 70-year-old Japanese woman with acromegaly, who complained of bilateral finger stiffness and polyarthralgia two months after transsphenoidal surgery of a growth hormone (GH)-secreting pituitary adenoma. Postoperative levels of serum GH and insulin-like growth factor-1 (IGF-1) were markedly decreased without any secretory deficiency of other anterior pituitary hormones. Hand X-ray did not show typical RA changes; however, erosive changes in carpal bones were clearly detected by magnetic resonance imaging with gadolinium enhancement. Based on the levels of serological markers in the patient following surgery including C-reactive protein, rheumatoid factor and matrix metalloproteinase-3, anti-rheumatic therapy was subsequently commenced. Regardless of the levels of GH and IGF-1, acromegaly patients frequently complain about joint-related symptoms even after remission. Therefore, careful observation of bone erosive changes and immunological activity in acromegaly patients is required when joint-related symptoms persist.

KW - Acromegaly

KW - Arthropathy

KW - Growth hormone

KW - Pituitary adenoma

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=33750618083&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750618083&partnerID=8YFLogxK

U2 - 10.1507/endocrj.K06-043

DO - 10.1507/endocrj.K06-043

M3 - Article

C2 - 16896264

AN - SCOPUS:33750618083

VL - 53

SP - 621

EP - 625

JO - Endocrine Journal

JF - Endocrine Journal

SN - 0918-8959

IS - 5

ER -