Management of peritoneal effusion by sealing with a self-assembling nanofiber polypeptide following pelvic surgery.

Yoshitaka Kondo, Takeshi Nagasaka, Satoru Kobayashi, Naoya Kobayashi, Toshiyoshi Fujiwara

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

PuraMatrix is a synthetic material consisting of 16-amino acid peptides that self-assemble into nanofibers, previously used as a scaffold for functional cell cultures. We conducted a clinical study to determine the safety and sealing properties of PuraMatrix in post-operative lymphorrhea following pelvic surgery in humans. A total of 20 patients who underwent rectal cancer resection were analyzed. The study group (n = 10) consisted of patients who received PuraMatrix, matched with a control group (n = 10) of patients operated on conventionally. During the 2 to 3 month follow-up period, there were no abnormal findings or adverse events in any the patients who received PuraMatrix. We found that the patients who received PuraMatrix had significantly reduced post-operative drainage volumes compared with the patients in the control group. PuraMatrix is a safe and effective bio-compatible sealing material for the management of post-operative peritoneal effusion following pelvic surgery.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalHepato-gastroenterology
Volume61
Issue number130
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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