Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene

Masaya Iwamuro, Ryuta Takenaka, Masahiro Nakagawa, Yuki Moritou, Shunsuke Saito, Shinichiro Hori, Tomoki Inaba, Yoshinari Kawai, Tatsuya Toyokawa, Takehiro Tanaka, Tadashi Yoshino, Hiroyuki Okada

Research output: Contribution to journalArticle

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Abstract

AIM To identify the clinical features of gastric mucosaassociated lymphoid tissue (MALT) lymphoma with extra copies of MALT1 . METHODS This is a multi-centered, retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1 (Group A, n = 88), patients with t(11;18) translocation (Group B, n = 27), and patients with extra copies of MALT1 (Group C, n = 31). The clinical background, treatment, and outcomes of each group were investigated. RESULTS Groups A and C showed slight female predominance, whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A (69.3%), 22 in Group B (81.5%), and 21 in Group C (67.7%). Helicobacter pylori (H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B, 14 patients underwent radiotherapy alone, which resulted in lymphoma disappearance. Although the difference was not statistically significant, event-free survival in Group C tended to be inferior to that in Group A (p = 0.10). CONCLUSION Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication, similar to patients without t(11;18) translocation or extra copies of MALT1 .

Original languageEnglish
Pages (from-to)6155-6163
Number of pages9
JournalWorld Journal of Gastroenterology
Volume23
Issue number33
DOIs
Publication statusPublished - Sep 7 2017

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Marginal Zone B-Cell Lymphoma
Gastric Mucosa
Genes
Lymphoma
Lymphoid Tissue
Helicobacter pylori
Stomach
Fluorescence In Situ Hybridization
Disease-Free Survival
Radiotherapy
Retrospective Studies

Keywords

  • Esophagogastroduodenoscopy
  • Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue
  • Gastric neoplasms
  • T(11;18) translocation
  • Trisomy 18

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene. / Iwamuro, Masaya; Takenaka, Ryuta; Nakagawa, Masahiro; Moritou, Yuki; Saito, Shunsuke; Hori, Shinichiro; Inaba, Tomoki; Kawai, Yoshinari; Toyokawa, Tatsuya; Tanaka, Takehiro; Yoshino, Tadashi; Okada, Hiroyuki.

In: World Journal of Gastroenterology, Vol. 23, No. 33, 07.09.2017, p. 6155-6163.

Research output: Contribution to journalArticle

Iwamuro, Masaya ; Takenaka, Ryuta ; Nakagawa, Masahiro ; Moritou, Yuki ; Saito, Shunsuke ; Hori, Shinichiro ; Inaba, Tomoki ; Kawai, Yoshinari ; Toyokawa, Tatsuya ; Tanaka, Takehiro ; Yoshino, Tadashi ; Okada, Hiroyuki. / Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene. In: World Journal of Gastroenterology. 2017 ; Vol. 23, No. 33. pp. 6155-6163.
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abstract = "AIM To identify the clinical features of gastric mucosaassociated lymphoid tissue (MALT) lymphoma with extra copies of MALT1 . METHODS This is a multi-centered, retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1 (Group A, n = 88), patients with t(11;18) translocation (Group B, n = 27), and patients with extra copies of MALT1 (Group C, n = 31). The clinical background, treatment, and outcomes of each group were investigated. RESULTS Groups A and C showed slight female predominance, whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A (69.3{\%}), 22 in Group B (81.5{\%}), and 21 in Group C (67.7{\%}). Helicobacter pylori (H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B, 14 patients underwent radiotherapy alone, which resulted in lymphoma disappearance. Although the difference was not statistically significant, event-free survival in Group C tended to be inferior to that in Group A (p = 0.10). CONCLUSION Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication, similar to patients without t(11;18) translocation or extra copies of MALT1 .",
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T1 - Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene

AU - Iwamuro, Masaya

AU - Takenaka, Ryuta

AU - Nakagawa, Masahiro

AU - Moritou, Yuki

AU - Saito, Shunsuke

AU - Hori, Shinichiro

AU - Inaba, Tomoki

AU - Kawai, Yoshinari

AU - Toyokawa, Tatsuya

AU - Tanaka, Takehiro

AU - Yoshino, Tadashi

AU - Okada, Hiroyuki

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N2 - AIM To identify the clinical features of gastric mucosaassociated lymphoid tissue (MALT) lymphoma with extra copies of MALT1 . METHODS This is a multi-centered, retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1 (Group A, n = 88), patients with t(11;18) translocation (Group B, n = 27), and patients with extra copies of MALT1 (Group C, n = 31). The clinical background, treatment, and outcomes of each group were investigated. RESULTS Groups A and C showed slight female predominance, whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A (69.3%), 22 in Group B (81.5%), and 21 in Group C (67.7%). Helicobacter pylori (H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B, 14 patients underwent radiotherapy alone, which resulted in lymphoma disappearance. Although the difference was not statistically significant, event-free survival in Group C tended to be inferior to that in Group A (p = 0.10). CONCLUSION Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication, similar to patients without t(11;18) translocation or extra copies of MALT1 .

AB - AIM To identify the clinical features of gastric mucosaassociated lymphoid tissue (MALT) lymphoma with extra copies of MALT1 . METHODS This is a multi-centered, retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1 (Group A, n = 88), patients with t(11;18) translocation (Group B, n = 27), and patients with extra copies of MALT1 (Group C, n = 31). The clinical background, treatment, and outcomes of each group were investigated. RESULTS Groups A and C showed slight female predominance, whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A (69.3%), 22 in Group B (81.5%), and 21 in Group C (67.7%). Helicobacter pylori (H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B, 14 patients underwent radiotherapy alone, which resulted in lymphoma disappearance. Although the difference was not statistically significant, event-free survival in Group C tended to be inferior to that in Group A (p = 0.10). CONCLUSION Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication, similar to patients without t(11;18) translocation or extra copies of MALT1 .

KW - Esophagogastroduodenoscopy

KW - Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue

KW - Gastric neoplasms

KW - T(11;18) translocation

KW - Trisomy 18

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