[Management of cardiopulmonary bypass during cardiac surgery for patients with heparin-induced thrombocytopenia].

Taichi Kondo, Masanori Hirota, Joji Hoshino, Yasuhisa Fukada, Tadashi Isomura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We experienced 4 cases of open heart surgeries under preoperative diagnosis of heparin-induced thrombocytopenia(HIT). We performed operation with argatroban instead of heparin. The argatroban was administered intravenously with a bolus of 100 μg/kg. After activated clotting time(ACT)reached over 200 seconds, continuous infusion of argatroban was started, 1~2 μg/kg/min until the level of ACT over 250 in the case of off-pump coronary artery bypass grafting(OPCAB), with 6~10 μg/kg/min, or the level of ACT over 400 with the use of cardiopulmonary bypass (CPB). All cases required more than 60 minutes to achieve the target ACT level after starting the argatroban. In 1 case it was impossible to achieve target level of ACT by argatroban alone, and heparin was used concomitantly. In 1 case there was a complication of membrane occlusion of CPB. Open cardiac surgery with the use of argatroban required specific care for coagulation to complete operation.

Original languageEnglish
Pages (from-to)366-369
Number of pages4
JournalKyobu geka. The Japanese journal of thoracic surgery
Volume66
Issue number5
Publication statusPublished - May 2013
Externally publishedYes

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Cardiopulmonary Bypass
Thrombocytopenia
Thoracic Surgery
Heparin
Off-Pump Coronary Artery Bypass
Coronary Artery Bypass
argatroban
Membranes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

[Management of cardiopulmonary bypass during cardiac surgery for patients with heparin-induced thrombocytopenia]. / Kondo, Taichi; Hirota, Masanori; Hoshino, Joji; Fukada, Yasuhisa; Isomura, Tadashi.

In: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 66, No. 5, 05.2013, p. 366-369.

Research output: Contribution to journalArticle

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