Malignant Schwannoma Arising in the Intracranial Trigeminal Nerve. A Report of an Autopsy Case and a Review of the Literature

Yasushi Horie, Seiji Akagi, Kohji Taguchi, Tadashi Yoshino, Kazuhiko Hayashi, Kiyoshi Takahashi, Tadaatsu Akagi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

An autopsy case of malignant schwannoma arising in the intracranial trigeminal nerve is reported. The tumor involved the right cerebellopontine angle of the brain stem in an 18‐year‐old man. The spindle‐shaped tumor cells with eosinophilic cytoplasm proliferated in fascicles and exhibited hypercellularity, pleomorphisrn, increased mitotic activity and invasive growth. Ultrastructurally, inter‐digitating cytoplasmic processes and a few fragmented basal lamina‐like structures were observed. Immunohistochemically, some tumor cells were reactive with conventional anti‐S‐100 protein antibody, but negative for β subunit. Most tumor cells were positive for LY subunit of S‐100 protein. This is the eighth reported case of malignant schwannoma arising in the intracranial trigeminal nerve. Acta Pathol Jpn 40: 219‐225, 1990.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalPathology International
Volume40
Issue number3
DOIs
Publication statusPublished - Mar 1990

Keywords

  • Immunohistochemistry
  • Intracranial neoplasm
  • Malignant schwannoma
  • S‐100 protein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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