TY - JOUR
T1 - MALIGNANT HEMANGIOENDOTHELIOMA
AU - IHDA, HAZUKI
AU - TOKURA, YOSHIKI
AU - FUSHIMI, MISAO
AU - YOKOTE, RYUICHI
AU - HASHIZUME, HIDEO
AU - SHIRAHAMA, SHIGEHO
AU - IWATSUKI, KEIJI
AU - MURAKAMI, KYOKO
AU - TAKIGAWA, MASAHIRO
PY - 1995/11
Y1 - 1995/11
N2 - Background. The administration of interleukin‐2 (il‐2) has recently been reported to be favorable for treating malignant hemangioendothelioma (mhe). Methods. Two patients with mhe responded well to intra‐lesional injections of recombinant il‐2 (ril‐2) without major side effects. The purpose of this study was to characterize cells infiltrating the regressing tumor following ril‐2 treatment. Immunohistochemical studies were performed on biopsy specimens taken from ril‐2‐injected lesional skin. Results. It was shown that CD8+ lymphocytes and CD56+ natural killer (nk) cells infiltrated at the ril‐2‐injection sites, suggesting that these cells contributed to the tumor regression. In addition, MHE cells bore intercellular adhesion mole‐cule‐1 (icam‐1) whose expression was augmented by rn‐2 injections. Conclusions. These findings suggested, that ril‐2 not only induces lymphokine‐activated killer (lak) cells and nk cells, but also facilitates these cytotoxic cells to adhere to MHE cells by enhancing icam‐1 expression of tumor cells.
AB - Background. The administration of interleukin‐2 (il‐2) has recently been reported to be favorable for treating malignant hemangioendothelioma (mhe). Methods. Two patients with mhe responded well to intra‐lesional injections of recombinant il‐2 (ril‐2) without major side effects. The purpose of this study was to characterize cells infiltrating the regressing tumor following ril‐2 treatment. Immunohistochemical studies were performed on biopsy specimens taken from ril‐2‐injected lesional skin. Results. It was shown that CD8+ lymphocytes and CD56+ natural killer (nk) cells infiltrated at the ril‐2‐injection sites, suggesting that these cells contributed to the tumor regression. In addition, MHE cells bore intercellular adhesion mole‐cule‐1 (icam‐1) whose expression was augmented by rn‐2 injections. Conclusions. These findings suggested, that ril‐2 not only induces lymphokine‐activated killer (lak) cells and nk cells, but also facilitates these cytotoxic cells to adhere to MHE cells by enhancing icam‐1 expression of tumor cells.
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U2 - 10.1111/j.1365-4362.1995.tb04406.x
DO - 10.1111/j.1365-4362.1995.tb04406.x
M3 - Article
C2 - 8543420
AN - SCOPUS:0028844072
SN - 0011-9059
VL - 34
SP - 811
EP - 816
JO - International Journal of Dermatology
JF - International Journal of Dermatology
IS - 11
ER -