Major determinants in hepatic disposition of polystyrene nanospheres: Implication for rational design of particulate drug carriers

Ken ichi Ogawara, Kazutaka Higaki, Toshikiro Kimura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The clearance of colloidal particles from the blood circulation occurs by phagocytes and/or endothelial cells, mainly in the liver, the spleen, and the bone marrow. The relative distribution of the injected particles in these organs is known to depend on various factors such as the size and surface properties of the particles and the type of serum proteins adsorbed onto the surface of particles. The basic principles behind their distribution characteristics into the reticuloendothelial system, however, remain unclear. This article reviews major determinants in hepatic disposition of polystyrene nanospheres, especially the relationship among physicochemical properties of the particle surface, the type of blood components associated onto the surface of particles, and their in vivo disposition characteristics in rats, and considerations to be given and implication for the rational design of particulate drug carriers are discussed.

Original languageEnglish
Pages (from-to)277-306
Number of pages30
JournalCritical Reviews in Therapeutic Drug Carrier Systems
Volume19
Issue number4-5
DOIs
Publication statusPublished - 2002

Fingerprint

Nanospheres
Drug Carriers
Surface Properties
Polystyrenes
Mononuclear Phagocyte System
Blood Circulation
Liver
Phagocytes
Blood Proteins
Spleen
Endothelial Cells
Bone Marrow

Keywords

  • Dysopsonin
  • Opsonin
  • Perfused rat liver
  • Polystyrene nanosphere
  • Receptor-mediated phagocytosis

ASJC Scopus subject areas

  • Pharmacology

Cite this

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abstract = "The clearance of colloidal particles from the blood circulation occurs by phagocytes and/or endothelial cells, mainly in the liver, the spleen, and the bone marrow. The relative distribution of the injected particles in these organs is known to depend on various factors such as the size and surface properties of the particles and the type of serum proteins adsorbed onto the surface of particles. The basic principles behind their distribution characteristics into the reticuloendothelial system, however, remain unclear. This article reviews major determinants in hepatic disposition of polystyrene nanospheres, especially the relationship among physicochemical properties of the particle surface, the type of blood components associated onto the surface of particles, and their in vivo disposition characteristics in rats, and considerations to be given and implication for the rational design of particulate drug carriers are discussed.",
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T2 - Implication for rational design of particulate drug carriers

AU - Ogawara, Ken ichi

AU - Higaki, Kazutaka

AU - Kimura, Toshikiro

PY - 2002

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