Magnifying narrowband imaging is more accurate than conventional white-light imaging in diagnosis of gastric mucosal cancer

Yasumasa Ezoe, Manabu Muto, Noriya Uedo, Hisashi Doyama, Kenshi Yao, Ichiro Oda, Kazuhiro Kaneko, Yoshiro Kawahara, Chizu Yokoi, Yasushi Sugiura, Hideki Ishikawa, Yoji Takeuchi, Yoshibumi Kaneko, Yutaka Saito

Research output: Contribution to journalArticle

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Abstract

Background & Aims: It is difficult to accurately diagnose patients with depressed gastric mucosal cancer based on conventional white-light imaging (C-WLI) endoscopy. We compared the real-time diagnostic yield of C-WLI for small, depressed gastric mucosal cancers with that of magnifying narrow-band imaging (M-NBI). Methods: We performed a multicenter, prospective, randomized, controlled trial of patients with undiagnosed depressed lesions ≤10 mm in diameter identified by esophagogastroduodenoscopy. Patients were randomly assigned to groups that were analyzed by C-WLI (n = 176) or M-NBI (n = 177) immediately after detection; the C-WLI group received M-NBI after C-WLI. We compared the diagnostic accuracy, sensitivity, and specificity between C-WLI and M-NBI and assessed the diagnostic yield of M-NBI conducted in conjunction with C-WLI. Results: Overall, 40 gastric cancers (20 in each group) were identified. The median diagnostic values for M-NBI and C-WLI were as follows: accuracy, 90.4% and 64.8%; sensitivity, 60.0% and 40.0%; and specificity, 94.3% and 67.9%, respectively. The accuracy and specificity of M-NBI were greater than those of C-WLI (P

Original languageEnglish
JournalGastroenterology
Volume141
Issue number6
DOIs
Publication statusPublished - Dec 2011

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Narrow Band Imaging
Stomach Neoplasms
Light
Digestive System Endoscopy
Endoscopy
Randomized Controlled Trials

Keywords

  • Benign
  • Biopsy
  • Early Detection
  • Gastric Cancer
  • Malignant
  • Neoplasm

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Magnifying narrowband imaging is more accurate than conventional white-light imaging in diagnosis of gastric mucosal cancer. / Ezoe, Yasumasa; Muto, Manabu; Uedo, Noriya; Doyama, Hisashi; Yao, Kenshi; Oda, Ichiro; Kaneko, Kazuhiro; Kawahara, Yoshiro; Yokoi, Chizu; Sugiura, Yasushi; Ishikawa, Hideki; Takeuchi, Yoji; Kaneko, Yoshibumi; Saito, Yutaka.

In: Gastroenterology, Vol. 141, No. 6, 12.2011.

Research output: Contribution to journalArticle

Ezoe, Y, Muto, M, Uedo, N, Doyama, H, Yao, K, Oda, I, Kaneko, K, Kawahara, Y, Yokoi, C, Sugiura, Y, Ishikawa, H, Takeuchi, Y, Kaneko, Y & Saito, Y 2011, 'Magnifying narrowband imaging is more accurate than conventional white-light imaging in diagnosis of gastric mucosal cancer', Gastroenterology, vol. 141, no. 6. https://doi.org/10.1053/j.gastro.2011.08.007
Ezoe, Yasumasa ; Muto, Manabu ; Uedo, Noriya ; Doyama, Hisashi ; Yao, Kenshi ; Oda, Ichiro ; Kaneko, Kazuhiro ; Kawahara, Yoshiro ; Yokoi, Chizu ; Sugiura, Yasushi ; Ishikawa, Hideki ; Takeuchi, Yoji ; Kaneko, Yoshibumi ; Saito, Yutaka. / Magnifying narrowband imaging is more accurate than conventional white-light imaging in diagnosis of gastric mucosal cancer. In: Gastroenterology. 2011 ; Vol. 141, No. 6.
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AU - Muto, Manabu

AU - Uedo, Noriya

AU - Doyama, Hisashi

AU - Yao, Kenshi

AU - Oda, Ichiro

AU - Kaneko, Kazuhiro

AU - Kawahara, Yoshiro

AU - Yokoi, Chizu

AU - Sugiura, Yasushi

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AU - Takeuchi, Yoji

AU - Kaneko, Yoshibumi

AU - Saito, Yutaka

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