Magnifying endoscopical and immunohistchemical study of duodenitis

Observation of duodenal mucosa was made by using a magnifying endoscope (OLYMPUS, GIF-D10), and classification of three patterns was established, namely, the isolated pattern, the connected pattern and atrophic pattern. These magnifying endoscopic patterns are based on the shape of the duodenal villi, and also recognisable with an ordinary endoscope using the indigo-carmine dye contrast method. In our study, these magnified endoscopic duodenal mucosal patterns had asignificant relationship with the ordinary endoscopic picture of duodenitis. Sixty one and half percent of the normal control acses had an isolated pattern. In contrast, the isolated pattern decreased in number in hyperemic and erosive type duodenitis and none of the rough surfaced type duodenitis showed this pattern. On the other hand, 80.0 % of rough surfaced type duodenitis had the atrophic pattern. In bioptic study, inflammatory cells had significantly increased in hyperemic and erosive type duodenitis, and gastric metaplasia was characteristic in the rough surfaced type duodenitis. Amount of Cu-Zn super oxide dismutase in the duodenal mucosa of duodenitis was found to be in between the control and duodenal ulcer, except erosive type which showed low value as duodenal ulcer. In the cases of duodenitis, labellding index of duodenal mucosa of proliferative zone was higher than that of the control.