Magnetocardiography study on ventricular depolarization-current pattern in patients with Brugada syndrome and complete right-bundle branch blocks

Akihiko Kandori, Tsuyoshi Miyashita, Kuniomi Ogata, Wataru Shimizu, Miki Yokokawa, Shiro Kamakura, Kunio Miyatake, Keiji Tsukada, Satsuki Yamada, Shigeyuki Watanabe, Iwao Yamaguchi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: The objective of this study is to use magnetocardiography to determine the existence of a small abnormal current during ventricular depolarization in patients with Brugada syndrome. To understand this small difference in abnormal current during ventricular depolarization, we compared abnormal currents of patients with cases of complete right-bundle-branch block (CRBBB). Methods and Results: We developed a whole-heart electrical bull's eye map (WHEBEM) that uses magnetocardiograms (MCGs) to visualize the current distribution in a circular map. MCGs of Brugada syndrome patients (n = 16), CRBBB patients (n = 10), and controls (n = 12) at rest were recorded. In the WHEBEMs of Brugada syndrome patients, the magnitude of the S-wave current in the upper-right direction of the anterior side is larger than that of the controls. In addition, the R-wave current direction is similar to that of the controls, and the R-wave vector is distributed over a larger area than that of the controls. On the other hand, the CRBBB patients have a distribution of R-wave currents over a larger area in the left anteromedian region and the left posteromedian region. Moreover, in all CRBBB patients, S-wave currents with a large magnitude have the same direction distributed over a small area. Conclusions: The WHEBEM findings suggest that there is an abnormal current in the direction to the upper right (in the S-wave) in the anterosuperior region of Brugada syndrome patients. We thus conclude that a WHEBEM has the potential to detect characteristics of heart disease.

Original languageEnglish
Pages (from-to)1359-1367
Number of pages9
JournalPACE - Pacing and Clinical Electrophysiology
Volume29
Issue number12
DOIs
Publication statusPublished - Dec 2006

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Magnetocardiography
Brugada Syndrome
Bundle-Branch Block
Heart Diseases

Keywords

  • Arrhythmia
  • Brugada syndrome
  • Depolarization
  • Magnetocardiogram
  • Right-bundle-branch block

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Magnetocardiography study on ventricular depolarization-current pattern in patients with Brugada syndrome and complete right-bundle branch blocks. / Kandori, Akihiko; Miyashita, Tsuyoshi; Ogata, Kuniomi; Shimizu, Wataru; Yokokawa, Miki; Kamakura, Shiro; Miyatake, Kunio; Tsukada, Keiji; Yamada, Satsuki; Watanabe, Shigeyuki; Yamaguchi, Iwao.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 29, No. 12, 12.2006, p. 1359-1367.

Research output: Contribution to journalArticle

Kandori, A, Miyashita, T, Ogata, K, Shimizu, W, Yokokawa, M, Kamakura, S, Miyatake, K, Tsukada, K, Yamada, S, Watanabe, S & Yamaguchi, I 2006, 'Magnetocardiography study on ventricular depolarization-current pattern in patients with Brugada syndrome and complete right-bundle branch blocks', PACE - Pacing and Clinical Electrophysiology, vol. 29, no. 12, pp. 1359-1367. https://doi.org/10.1111/j.1540-8159.2006.00548.x
Kandori, Akihiko ; Miyashita, Tsuyoshi ; Ogata, Kuniomi ; Shimizu, Wataru ; Yokokawa, Miki ; Kamakura, Shiro ; Miyatake, Kunio ; Tsukada, Keiji ; Yamada, Satsuki ; Watanabe, Shigeyuki ; Yamaguchi, Iwao. / Magnetocardiography study on ventricular depolarization-current pattern in patients with Brugada syndrome and complete right-bundle branch blocks. In: PACE - Pacing and Clinical Electrophysiology. 2006 ; Vol. 29, No. 12. pp. 1359-1367.
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AU - Kandori, Akihiko

AU - Miyashita, Tsuyoshi

AU - Ogata, Kuniomi

AU - Shimizu, Wataru

AU - Yokokawa, Miki

AU - Kamakura, Shiro

AU - Miyatake, Kunio

AU - Tsukada, Keiji

AU - Yamada, Satsuki

AU - Watanabe, Shigeyuki

AU - Yamaguchi, Iwao

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N2 - Background: The objective of this study is to use magnetocardiography to determine the existence of a small abnormal current during ventricular depolarization in patients with Brugada syndrome. To understand this small difference in abnormal current during ventricular depolarization, we compared abnormal currents of patients with cases of complete right-bundle-branch block (CRBBB). Methods and Results: We developed a whole-heart electrical bull's eye map (WHEBEM) that uses magnetocardiograms (MCGs) to visualize the current distribution in a circular map. MCGs of Brugada syndrome patients (n = 16), CRBBB patients (n = 10), and controls (n = 12) at rest were recorded. In the WHEBEMs of Brugada syndrome patients, the magnitude of the S-wave current in the upper-right direction of the anterior side is larger than that of the controls. In addition, the R-wave current direction is similar to that of the controls, and the R-wave vector is distributed over a larger area than that of the controls. On the other hand, the CRBBB patients have a distribution of R-wave currents over a larger area in the left anteromedian region and the left posteromedian region. Moreover, in all CRBBB patients, S-wave currents with a large magnitude have the same direction distributed over a small area. Conclusions: The WHEBEM findings suggest that there is an abnormal current in the direction to the upper right (in the S-wave) in the anterosuperior region of Brugada syndrome patients. We thus conclude that a WHEBEM has the potential to detect characteristics of heart disease.

AB - Background: The objective of this study is to use magnetocardiography to determine the existence of a small abnormal current during ventricular depolarization in patients with Brugada syndrome. To understand this small difference in abnormal current during ventricular depolarization, we compared abnormal currents of patients with cases of complete right-bundle-branch block (CRBBB). Methods and Results: We developed a whole-heart electrical bull's eye map (WHEBEM) that uses magnetocardiograms (MCGs) to visualize the current distribution in a circular map. MCGs of Brugada syndrome patients (n = 16), CRBBB patients (n = 10), and controls (n = 12) at rest were recorded. In the WHEBEMs of Brugada syndrome patients, the magnitude of the S-wave current in the upper-right direction of the anterior side is larger than that of the controls. In addition, the R-wave current direction is similar to that of the controls, and the R-wave vector is distributed over a larger area than that of the controls. On the other hand, the CRBBB patients have a distribution of R-wave currents over a larger area in the left anteromedian region and the left posteromedian region. Moreover, in all CRBBB patients, S-wave currents with a large magnitude have the same direction distributed over a small area. Conclusions: The WHEBEM findings suggest that there is an abnormal current in the direction to the upper right (in the S-wave) in the anterosuperior region of Brugada syndrome patients. We thus conclude that a WHEBEM has the potential to detect characteristics of heart disease.

KW - Arrhythmia

KW - Brugada syndrome

KW - Depolarization

KW - Magnetocardiogram

KW - Right-bundle-branch block

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