Magnetocardiographic determination of the developmental changes in PQ, QRS and QT intervals in the foetus

H. Horigome, M. I. Takahashi, M. Asaka, S. Shigemitsu, A. Kandori, Keiji Tsukada

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

In order to determine developmental changes in atrioventricular (PQ), ventricular depolarizing (QRS) and QT intervals of the foetal heart, we recorded foetal magnetocardiographic waveforms using a superconducting quantum interference device system in a magnetically shielded room in 150 uncomplicated foetuses of gestational age >20 wk. Recording of the QRS waveform was successful in 128 (85%) of the subjects, based on unaveraged tracings. After signal averaging of the data from these 128 cases, P waves were recognized in 102 (68%) subjects and T waves in 64 (43%). The QRS interval, ranging from 32-74 ms, showed a positive linear correlation with the gestational age, which probably reflects an increase in the number and size of myocardial cells. The PQ interval showed low correlation with the gestational age, and was rather constant, with an average value of 100 ms. The QT interval ranged from 180-302 ms, and tended to be slightly shorter during early gestation. Although the success rate of measuring the PQ and QT intervals was unsatisfactory for this methodology to prevail in a clinical setting, these values provide the basis for in utero non-invasive investigation of foetal cardiac activity by magnetocardiography.

Original languageEnglish
Pages (from-to)64-67
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics
Volume89
Issue number1
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Gestational Age
Fetus
Magnetocardiography
Fetal Heart
Fetal Movement
Cell Size
Equipment and Supplies
Pregnancy

Keywords

  • Cardiac conduction system
  • Foetal magnetocardiography
  • Prenatal diagnosis
  • Superconducting quantum interference device

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Magnetocardiographic determination of the developmental changes in PQ, QRS and QT intervals in the foetus. / Horigome, H.; Takahashi, M. I.; Asaka, M.; Shigemitsu, S.; Kandori, A.; Tsukada, Keiji.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 89, No. 1, 2000, p. 64-67.

Research output: Contribution to journalArticle

Horigome, H. ; Takahashi, M. I. ; Asaka, M. ; Shigemitsu, S. ; Kandori, A. ; Tsukada, Keiji. / Magnetocardiographic determination of the developmental changes in PQ, QRS and QT intervals in the foetus. In: Acta Paediatrica, International Journal of Paediatrics. 2000 ; Vol. 89, No. 1. pp. 64-67.
@article{3920b33f8c404628993b9f24ec040a10,
title = "Magnetocardiographic determination of the developmental changes in PQ, QRS and QT intervals in the foetus",
abstract = "In order to determine developmental changes in atrioventricular (PQ), ventricular depolarizing (QRS) and QT intervals of the foetal heart, we recorded foetal magnetocardiographic waveforms using a superconducting quantum interference device system in a magnetically shielded room in 150 uncomplicated foetuses of gestational age >20 wk. Recording of the QRS waveform was successful in 128 (85{\%}) of the subjects, based on unaveraged tracings. After signal averaging of the data from these 128 cases, P waves were recognized in 102 (68{\%}) subjects and T waves in 64 (43{\%}). The QRS interval, ranging from 32-74 ms, showed a positive linear correlation with the gestational age, which probably reflects an increase in the number and size of myocardial cells. The PQ interval showed low correlation with the gestational age, and was rather constant, with an average value of 100 ms. The QT interval ranged from 180-302 ms, and tended to be slightly shorter during early gestation. Although the success rate of measuring the PQ and QT intervals was unsatisfactory for this methodology to prevail in a clinical setting, these values provide the basis for in utero non-invasive investigation of foetal cardiac activity by magnetocardiography.",
keywords = "Cardiac conduction system, Foetal magnetocardiography, Prenatal diagnosis, Superconducting quantum interference device",
author = "H. Horigome and Takahashi, {M. I.} and M. Asaka and S. Shigemitsu and A. Kandori and Keiji Tsukada",
year = "2000",
language = "English",
volume = "89",
pages = "64--67",
journal = "Acta Paediatrica, International Journal of Paediatrics",
issn = "0803-5253",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Magnetocardiographic determination of the developmental changes in PQ, QRS and QT intervals in the foetus

AU - Horigome, H.

AU - Takahashi, M. I.

AU - Asaka, M.

AU - Shigemitsu, S.

AU - Kandori, A.

AU - Tsukada, Keiji

PY - 2000

Y1 - 2000

N2 - In order to determine developmental changes in atrioventricular (PQ), ventricular depolarizing (QRS) and QT intervals of the foetal heart, we recorded foetal magnetocardiographic waveforms using a superconducting quantum interference device system in a magnetically shielded room in 150 uncomplicated foetuses of gestational age >20 wk. Recording of the QRS waveform was successful in 128 (85%) of the subjects, based on unaveraged tracings. After signal averaging of the data from these 128 cases, P waves were recognized in 102 (68%) subjects and T waves in 64 (43%). The QRS interval, ranging from 32-74 ms, showed a positive linear correlation with the gestational age, which probably reflects an increase in the number and size of myocardial cells. The PQ interval showed low correlation with the gestational age, and was rather constant, with an average value of 100 ms. The QT interval ranged from 180-302 ms, and tended to be slightly shorter during early gestation. Although the success rate of measuring the PQ and QT intervals was unsatisfactory for this methodology to prevail in a clinical setting, these values provide the basis for in utero non-invasive investigation of foetal cardiac activity by magnetocardiography.

AB - In order to determine developmental changes in atrioventricular (PQ), ventricular depolarizing (QRS) and QT intervals of the foetal heart, we recorded foetal magnetocardiographic waveforms using a superconducting quantum interference device system in a magnetically shielded room in 150 uncomplicated foetuses of gestational age >20 wk. Recording of the QRS waveform was successful in 128 (85%) of the subjects, based on unaveraged tracings. After signal averaging of the data from these 128 cases, P waves were recognized in 102 (68%) subjects and T waves in 64 (43%). The QRS interval, ranging from 32-74 ms, showed a positive linear correlation with the gestational age, which probably reflects an increase in the number and size of myocardial cells. The PQ interval showed low correlation with the gestational age, and was rather constant, with an average value of 100 ms. The QT interval ranged from 180-302 ms, and tended to be slightly shorter during early gestation. Although the success rate of measuring the PQ and QT intervals was unsatisfactory for this methodology to prevail in a clinical setting, these values provide the basis for in utero non-invasive investigation of foetal cardiac activity by magnetocardiography.

KW - Cardiac conduction system

KW - Foetal magnetocardiography

KW - Prenatal diagnosis

KW - Superconducting quantum interference device

UR - http://www.scopus.com/inward/record.url?scp=0033979861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033979861&partnerID=8YFLogxK

M3 - Article

C2 - 10677060

AN - SCOPUS:0033979861

VL - 89

SP - 64

EP - 67

JO - Acta Paediatrica, International Journal of Paediatrics

JF - Acta Paediatrica, International Journal of Paediatrics

SN - 0803-5253

IS - 1

ER -