Magneto-encephalographic measurement of neural activity during period of vertigo induced by cold caloric stimulation

Akihiko Kandori, Hiroshi Oe, Kotaro Miyashita, Shinji Ohira, Hiroaki Naritomi, Yoshihide Chiba, Kuniomi Ogata, Masahiro Murakami, Tsuyoshi Miyashita, Keiji Tsukada

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Abstract

The aim of this study was to investigate neural activity during period of vertiginous sensation, induced by caloric stimulation. After caloric vestibular stimulation (CVS) by cold water of five volunteers (n=5, age: 30±10), auditory evoked magnetic fields (AEFs) during the subsequent period of vertiginous sensations were measured by magnetoencephalography (MEG). Current-arrow maps (CAMs) were produced to estimate the spatial current distribution of the AEF responses, and a rotation value (dIrot) was calculated from the CAM. The worth of the dIrot values as indicators of vertigo was evaluated by comparing them with earlier reported values for elderly control (n=11, age: 67±5) and chronic dizziness (CD) (n=27, age: 68±8) groups (obtained from AEF responses with no the CVS). Although all volunteers felt vertigo during the AEF measurements, the AEF waveforms and CAM pattern only showed slight changes. While the dIrot values (1.43±0.73) just after CVS were not significantly different from those (1.59±0.46) for the elderly controls, they were significantly different from those (3.54±1.34) for the CD patients. These findings suggest that (i) the new parameter (dIrot) is more sensitively indicates dizziness (non-rotatory sensation) than vertigo (ii) the auditory cortical region may play an important role in body-balance perception of floating sensations.

Original languageEnglish
Pages (from-to)281-288
Number of pages8
JournalNeuroscience Research
Volume46
Issue number3
DOIs
Publication statusPublished - Jul 1 2003
Externally publishedYes

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Keywords

  • Auditory cortical function
  • Caloric vestibular stimuli
  • Current-arrow map
  • Dizziness
  • Magnetoencephalogram
  • Vertigo
  • Vestibular function

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kandori, A., Oe, H., Miyashita, K., Ohira, S., Naritomi, H., Chiba, Y., Ogata, K., Murakami, M., Miyashita, T., & Tsukada, K. (2003). Magneto-encephalographic measurement of neural activity during period of vertigo induced by cold caloric stimulation. Neuroscience Research, 46(3), 281-288. https://doi.org/10.1016/S0168-0102(03)00092-0