TY - JOUR
T1 - Magneto-encephalographic measurement of neural activity during period of vertigo induced by cold caloric stimulation
AU - Kandori, Akihiko
AU - Oe, Hiroshi
AU - Miyashita, Kotaro
AU - Ohira, Shinji
AU - Naritomi, Hiroaki
AU - Chiba, Yoshihide
AU - Ogata, Kuniomi
AU - Murakami, Masahiro
AU - Miyashita, Tsuyoshi
AU - Tsukada, Keiji
N1 - Funding Information:
This study was supported by Grant-in-Aid for Scientific Research No. 13072601 from the Ministry of Health, Labour and Welfare of Japan.
PY - 2003/7/1
Y1 - 2003/7/1
N2 - The aim of this study was to investigate neural activity during period of vertiginous sensation, induced by caloric stimulation. After caloric vestibular stimulation (CVS) by cold water of five volunteers (n=5, age: 30±10), auditory evoked magnetic fields (AEFs) during the subsequent period of vertiginous sensations were measured by magnetoencephalography (MEG). Current-arrow maps (CAMs) were produced to estimate the spatial current distribution of the AEF responses, and a rotation value (dIrot) was calculated from the CAM. The worth of the dIrot values as indicators of vertigo was evaluated by comparing them with earlier reported values for elderly control (n=11, age: 67±5) and chronic dizziness (CD) (n=27, age: 68±8) groups (obtained from AEF responses with no the CVS). Although all volunteers felt vertigo during the AEF measurements, the AEF waveforms and CAM pattern only showed slight changes. While the dIrot values (1.43±0.73) just after CVS were not significantly different from those (1.59±0.46) for the elderly controls, they were significantly different from those (3.54±1.34) for the CD patients. These findings suggest that (i) the new parameter (dIrot) is more sensitively indicates dizziness (non-rotatory sensation) than vertigo (ii) the auditory cortical region may play an important role in body-balance perception of floating sensations.
AB - The aim of this study was to investigate neural activity during period of vertiginous sensation, induced by caloric stimulation. After caloric vestibular stimulation (CVS) by cold water of five volunteers (n=5, age: 30±10), auditory evoked magnetic fields (AEFs) during the subsequent period of vertiginous sensations were measured by magnetoencephalography (MEG). Current-arrow maps (CAMs) were produced to estimate the spatial current distribution of the AEF responses, and a rotation value (dIrot) was calculated from the CAM. The worth of the dIrot values as indicators of vertigo was evaluated by comparing them with earlier reported values for elderly control (n=11, age: 67±5) and chronic dizziness (CD) (n=27, age: 68±8) groups (obtained from AEF responses with no the CVS). Although all volunteers felt vertigo during the AEF measurements, the AEF waveforms and CAM pattern only showed slight changes. While the dIrot values (1.43±0.73) just after CVS were not significantly different from those (1.59±0.46) for the elderly controls, they were significantly different from those (3.54±1.34) for the CD patients. These findings suggest that (i) the new parameter (dIrot) is more sensitively indicates dizziness (non-rotatory sensation) than vertigo (ii) the auditory cortical region may play an important role in body-balance perception of floating sensations.
KW - Auditory cortical function
KW - Caloric vestibular stimuli
KW - Current-arrow map
KW - Dizziness
KW - Magnetoencephalogram
KW - Vertigo
KW - Vestibular function
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U2 - 10.1016/S0168-0102(03)00092-0
DO - 10.1016/S0168-0102(03)00092-0
M3 - Article
C2 - 12804789
AN - SCOPUS:0038172223
SN - 0168-0102
VL - 46
SP - 281
EP - 288
JO - Neuroscience Research
JF - Neuroscience Research
IS - 3
ER -