Ma'edamines A and B, cytotoxic bromotyrosine alkaloids with a unique 2(1H)pyrazinone ring from sponge Suberea sp.

Keiko Hirano, Takaaki Kubota, Masashi Tsuda, Kenji Watanabe, Jane Fromont, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

Two new cytotoxic bromotyrosine alkaloids, ma'edamines A (1) and B (2), with a unique 2(1H)pyrazinone ring have been isolated from the Okinawan marine sponge Suberea sp. The structures were elucidated on the basis of spectroscopic data. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)8107-8110
Number of pages4
JournalTetrahedron
Volume56
Issue number41
DOIs
Publication statusPublished - Oct 6 2000
Externally publishedYes

Keywords

  • Bromotyrosine alkaloid
  • Pyrazinone
  • Sponge

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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