Macrophage infiltration and angiogenesis in endometrial cancer

I. Hashimoto, J. Kodama, N. Seki, A. Hongo, Y. Miyagi, M. Yoshinouchi, T. Kudo

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Abstract

The aim of this study was to determine whether tumor-associated macrophages (TAMs) infiltration correlates with clinicopathological factors including microvessel, counts and clinical outcome in endometrial cancer. Overall 56 out of the 109 endometrial cancers (51.4%) expressed distinct tumor-associated macrophages infiltration in their tumor stroma. Tumor-associated macrophages infiltration was significantly high in tumors with deep myometrial invasion, high grade and elderly patients. Microvessel counts strongly correlated with tumor-associated macrophages infiltration in tumor stroma (p=0.0002). However, tumor-associated macrophages infiltration was not a prognostic factor. In conclusion, tumor-associated macrophages may play a crucial role in the promotion of angiogenesis, but can not be used to prodict prognosis of patients with endometrial cancer.

Original languageEnglish
Pages (from-to)4853-4856
Number of pages4
JournalAnticancer Research
Volume20
Issue number6 C
Publication statusPublished - 2000

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Keywords

  • Angiogenesis
  • Endometrial cancer
  • Macrophage

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hashimoto, I., Kodama, J., Seki, N., Hongo, A., Miyagi, Y., Yoshinouchi, M., & Kudo, T. (2000). Macrophage infiltration and angiogenesis in endometrial cancer. Anticancer Research, 20(6 C), 4853-4856.