Abstract
The aim of this study was to determine whether tumor-associated macrophages (TAMs) infiltration correlates with clinicopathological factors including microvessel, counts and clinical outcome in endometrial cancer. Overall 56 out of the 109 endometrial cancers (51.4%) expressed distinct tumor-associated macrophages infiltration in their tumor stroma. Tumor-associated macrophages infiltration was significantly high in tumors with deep myometrial invasion, high grade and elderly patients. Microvessel counts strongly correlated with tumor-associated macrophages infiltration in tumor stroma (p=0.0002). However, tumor-associated macrophages infiltration was not a prognostic factor. In conclusion, tumor-associated macrophages may play a crucial role in the promotion of angiogenesis, but can not be used to prodict prognosis of patients with endometrial cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 4853-4856 |
| Number of pages | 4 |
| Journal | Anticancer research |
| Volume | 20 |
| Issue number | 6 C |
| Publication status | Published - Dec 1 2000 |
Keywords
- Angiogenesis
- Endometrial cancer
- Macrophage
ASJC Scopus subject areas
- Oncology
- Cancer Research