Macrocarquinoids A–C, new meroterpenoids from Sargassum macrocarpum

Hiromi Niwa, Shin ichiro Kurimoto, Takaaki Kubota, Mitsuhiro Sekiguchi

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract: The production and accumulation of advanced glycation end products (AGEs) have been implicated in diabetes and diabetic complication. This study was conducted as a search for an AGE inhibitor from brown alga, Sargassum macrocarpum. Separation and purification were performed using AGEs inhibitory activity as an index, yielding isolation of 11 meroterpenoids, of which 3 were new compounds: macrocarquinoids A (1), B (6), and C (9). Their structures were elucidated using NMR spectral analysis with 2D techniques. All tested compounds showed AGEs inhibitory activity. Particularly, macrocarquinoid C (9) possessed the strongest activity (IC50: 1.0 mM) of isolated compounds. This activity was stronger than that of aminoguanidine (positive control). Graphic abstract: [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)194-200
Number of pages7
JournalJournal of Natural Medicines
Volume75
Issue number1
DOIs
Publication statusPublished - Jan 2021
Externally publishedYes

Keywords

  • Advanced glycation end products
  • Brown alga
  • Meroterpenoid
  • Sargassum macrocarpum

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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