TY - JOUR
T1 - Lymphomatous polyp of mantle cell type in the duodenum complicated by gastric cancer
T2 - A case of trisomy 3 and t(11;14)(q13;q32)
AU - Tsuchiyama, J.
AU - Yoshino, T.
AU - Imajo, K.
AU - Kondou, E.
AU - Hamada, E.
AU - Tomiyama, Y.
AU - Toba, K.
AU - Furukawa, T.
AU - Fuse, I.
AU - Aizawa, Y.
AU - Harada, M.
AU - Tsubota, T.
PY - 2002/12/1
Y1 - 2002/12/1
N2 - We experienced a rare case of a lymphomatous polyp of mantle cell type forming a polypoid mass lesion in the duodenum bulbous together with advanced gastric cancer. A total gastrectomy was performed, and the specimen revealed atypical small- to medium-sized lymphoid cells with indented nuclei, which infiltrated the Peyer's patch and formed a nodular mass in the lamina propria and submucosa of the duodenum. The lymphoma cells also infiltrated the lymphoid follicle of the gastric mucosa, spleen, and regional lymph node with a typical mantle zone pattern. Flow cytometric analysis of the single cells of the lymph node and immunohistochemistry of a paraffin-embedded specimen revealed that the lymphoma cells expressed surface CD5, CD19, CD20, and nuclear cyclin D1. Chromosomal analysis of this single cell suspension revealed that these lymphoma cells have trisomy 3 in conjunction with t(11;14)(q13;q32), which is frequently seen in mucosa-associated lymphoid tissue lymphomas (MALToma) in the stomach and is also reported in mantle cell lymphoma as a secondary genetic alteration. Our report suggests that trisomy 3 may be a common chromosomal abnormality in lymphomatous polyps of mantle cell type.
AB - We experienced a rare case of a lymphomatous polyp of mantle cell type forming a polypoid mass lesion in the duodenum bulbous together with advanced gastric cancer. A total gastrectomy was performed, and the specimen revealed atypical small- to medium-sized lymphoid cells with indented nuclei, which infiltrated the Peyer's patch and formed a nodular mass in the lamina propria and submucosa of the duodenum. The lymphoma cells also infiltrated the lymphoid follicle of the gastric mucosa, spleen, and regional lymph node with a typical mantle zone pattern. Flow cytometric analysis of the single cells of the lymph node and immunohistochemistry of a paraffin-embedded specimen revealed that the lymphoma cells expressed surface CD5, CD19, CD20, and nuclear cyclin D1. Chromosomal analysis of this single cell suspension revealed that these lymphoma cells have trisomy 3 in conjunction with t(11;14)(q13;q32), which is frequently seen in mucosa-associated lymphoid tissue lymphomas (MALToma) in the stomach and is also reported in mantle cell lymphoma as a secondary genetic alteration. Our report suggests that trisomy 3 may be a common chromosomal abnormality in lymphomatous polyps of mantle cell type.
KW - Advanced gastric cancer
KW - Mantle cell lymphomatous polyp of duodenum
KW - Trisomy 3
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U2 - 10.1007/s00277-002-0434-y
DO - 10.1007/s00277-002-0434-y
M3 - Article
C2 - 11976826
AN - SCOPUS:0036934849
VL - 81
SP - 224
EP - 227
JO - Annals of Hematology
JF - Annals of Hematology
SN - 0939-5555
IS - 4
ER -