Lymphomatous polyp of mantle cell type in the duodenum complicated by gastric cancer: A case of trisomy 3 and t(11;14)(q13;q32)

J. Tsuchiyama, Tadashi Yoshino, K. Imajo, E. Kondou, E. Hamada, Y. Tomiyama, K. Toba, T. Furukawa, I. Fuse, Y. Aizawa, M. Harada, T. Tsubota

Research output: Contribution to journalArticle

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Abstract

We experienced a rare case of a lymphomatous polyp of mantle cell type forming a polypoid mass lesion in the duodenum bulbous together with advanced gastric cancer. A total gastrectomy was performed, and the specimen revealed atypical small- to medium-sized lymphoid cells with indented nuclei, which infiltrated the Peyer's patch and formed a nodular mass in the lamina propria and submucosa of the duodenum. The lymphoma cells also infiltrated the lymphoid follicle of the gastric mucosa, spleen, and regional lymph node with a typical mantle zone pattern. Flow cytometric analysis of the single cells of the lymph node and immunohistochemistry of a paraffin-embedded specimen revealed that the lymphoma cells expressed surface CD5, CD19, CD20, and nuclear cyclin D1. Chromosomal analysis of this single cell suspension revealed that these lymphoma cells have trisomy 3 in conjunction with t(11;14)(q13;q32), which is frequently seen in mucosa-associated lymphoid tissue lymphomas (MALToma) in the stomach and is also reported in mantle cell lymphoma as a secondary genetic alteration. Our report suggests that trisomy 3 may be a common chromosomal abnormality in lymphomatous polyps of mantle cell type.

Original languageEnglish
Pages (from-to)224-227
Number of pages4
JournalAnnals of Hematology
Volume81
Issue number4
DOIs
Publication statusPublished - 2002

Fingerprint

Trisomy
Polyps
Duodenum
Stomach Neoplasms
Single-Cell Analysis
Lymphoma
Lymph Nodes
Mantle-Cell Lymphoma
Peyer's Patches
Marginal Zone B-Cell Lymphoma
Cyclin D1
Gastrectomy
Gastric Mucosa
Chromosome Aberrations
Paraffin
Stomach
Suspensions
Mucous Membrane
Spleen
Immunohistochemistry

Keywords

  • Advanced gastric cancer
  • Mantle cell lymphomatous polyp of duodenum
  • Trisomy 3

ASJC Scopus subject areas

  • Hematology

Cite this

Lymphomatous polyp of mantle cell type in the duodenum complicated by gastric cancer : A case of trisomy 3 and t(11;14)(q13;q32). / Tsuchiyama, J.; Yoshino, Tadashi; Imajo, K.; Kondou, E.; Hamada, E.; Tomiyama, Y.; Toba, K.; Furukawa, T.; Fuse, I.; Aizawa, Y.; Harada, M.; Tsubota, T.

In: Annals of Hematology, Vol. 81, No. 4, 2002, p. 224-227.

Research output: Contribution to journalArticle

Tsuchiyama, J, Yoshino, T, Imajo, K, Kondou, E, Hamada, E, Tomiyama, Y, Toba, K, Furukawa, T, Fuse, I, Aizawa, Y, Harada, M & Tsubota, T 2002, 'Lymphomatous polyp of mantle cell type in the duodenum complicated by gastric cancer: A case of trisomy 3 and t(11;14)(q13;q32)', Annals of Hematology, vol. 81, no. 4, pp. 224-227. https://doi.org/10.1007/s00277-002-0434-y
Tsuchiyama, J. ; Yoshino, Tadashi ; Imajo, K. ; Kondou, E. ; Hamada, E. ; Tomiyama, Y. ; Toba, K. ; Furukawa, T. ; Fuse, I. ; Aizawa, Y. ; Harada, M. ; Tsubota, T. / Lymphomatous polyp of mantle cell type in the duodenum complicated by gastric cancer : A case of trisomy 3 and t(11;14)(q13;q32). In: Annals of Hematology. 2002 ; Vol. 81, No. 4. pp. 224-227.
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