Lymphomatous polyp of mantle cell type in the duodenum complicated by gastric cancer: A case of trisomy 3 and t(11;14)(q13;q32)

J. Tsuchiyama, T. Yoshino, K. Imajo, E. Kondou, E. Hamada, Y. Tomiyama, K. Toba, T. Furukawa, I. Fuse, Y. Aizawa, M. Harada, T. Tsubota

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Abstract

We experienced a rare case of a lymphomatous polyp of mantle cell type forming a polypoid mass lesion in the duodenum bulbous together with advanced gastric cancer. A total gastrectomy was performed, and the specimen revealed atypical small- to medium-sized lymphoid cells with indented nuclei, which infiltrated the Peyer's patch and formed a nodular mass in the lamina propria and submucosa of the duodenum. The lymphoma cells also infiltrated the lymphoid follicle of the gastric mucosa, spleen, and regional lymph node with a typical mantle zone pattern. Flow cytometric analysis of the single cells of the lymph node and immunohistochemistry of a paraffin-embedded specimen revealed that the lymphoma cells expressed surface CD5, CD19, CD20, and nuclear cyclin D1. Chromosomal analysis of this single cell suspension revealed that these lymphoma cells have trisomy 3 in conjunction with t(11;14)(q13;q32), which is frequently seen in mucosa-associated lymphoid tissue lymphomas (MALToma) in the stomach and is also reported in mantle cell lymphoma as a secondary genetic alteration. Our report suggests that trisomy 3 may be a common chromosomal abnormality in lymphomatous polyps of mantle cell type.

Original languageEnglish
Pages (from-to)224-227
Number of pages4
JournalAnnals of Hematology
Volume81
Issue number4
DOIs
Publication statusPublished - Dec 1 2002

Keywords

  • Advanced gastric cancer
  • Mantle cell lymphomatous polyp of duodenum
  • Trisomy 3

ASJC Scopus subject areas

  • Hematology

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    Tsuchiyama, J., Yoshino, T., Imajo, K., Kondou, E., Hamada, E., Tomiyama, Y., Toba, K., Furukawa, T., Fuse, I., Aizawa, Y., Harada, M., & Tsubota, T. (2002). Lymphomatous polyp of mantle cell type in the duodenum complicated by gastric cancer: A case of trisomy 3 and t(11;14)(q13;q32). Annals of Hematology, 81(4), 224-227. https://doi.org/10.1007/s00277-002-0434-y