Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum

Kan'ichiro Ishiuchi, Takaaki Kubota, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)

Abstract

Four new alkaloids, lycopladines B-D (1-3) and lyconadin B (4), have been isolated from the club moss Lycopodium complanatum and the structures including the stereochemistry were elucidated on the basis of spectral data and modified Mosher's method. Lyconadin B (4) elevated NGF mRNA expression in 1321N1 human astrocytoma cells.

Original languageEnglish
Pages (from-to)5995-6000
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume14
Issue number17
DOIs
Publication statusPublished - Sep 1 2006
Externally publishedYes

Keywords

  • Astrocytoma cells
  • Lyconadin B
  • Lycopladines B-D
  • Lycopodium alkaloids
  • NGF expression

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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