Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum

Kan'Ichiro Ishiuchi; Takaaki Kubota; Haruaki Ishiyama; Shigeki Hayashi; Toshiro Shibata; Koichiro Mori; Yutaro Obara; Norimichi Nakahata; Jun'Ichi Kobayashi

doi:10.1016/j.bmc.2010.12.025

Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum

Kan'Ichiro Ishiuchi, Takaaki Kubota, Haruaki Ishiyama, Shigeki Hayashi, Toshiro Shibata, Koichiro Mori, Yutaro Obara, Norimichi Nakahata, Jun'Ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Three new Lycopodium alkaloids, lyconadins D (1) and E (2), and complanadine E (3), were isolated from the club moss Lycopodium complanatum. Lyconadin D (1) was the first example of fastigiatine-type alkaloid isolated from Lycopodium complanatum. The structures and relative stereochemistry of 1-3 were elucidated on the basis of spectroscopic data. Complanadine E (3) enhanced mRNA expression for NGF.

Original language	English
Pages (from-to)	749-753
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/j.bmc.2010.12.025
Publication status	Published - Jan 15 2011
Externally published	Yes

Keywords

Complanadine E
Lyconadin D
Lyconadin E
Lycopodium alkaloids
Lycopodium complanatum

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2010.12.025

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title = "Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum",

abstract = "Three new Lycopodium alkaloids, lyconadins D (1) and E (2), and complanadine E (3), were isolated from the club moss Lycopodium complanatum. Lyconadin D (1) was the first example of fastigiatine-type alkaloid isolated from Lycopodium complanatum. The structures and relative stereochemistry of 1-3 were elucidated on the basis of spectroscopic data. Complanadine E (3) enhanced mRNA expression for NGF.",

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author = "Kan'Ichiro Ishiuchi and Takaaki Kubota and Haruaki Ishiyama and Shigeki Hayashi and Toshiro Shibata and Koichiro Mori and Yutaro Obara and Norimichi Nakahata and Jun'Ichi Kobayashi",

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doi = "10.1016/j.bmc.2010.12.025",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry",

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T1 - Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum

AU - Ishiuchi, Kan'Ichiro

AU - Kubota, Takaaki

AU - Ishiyama, Haruaki

AU - Hayashi, Shigeki

AU - Shibata, Toshiro

AU - Mori, Koichiro

AU - Obara, Yutaro

AU - Nakahata, Norimichi

AU - Kobayashi, Jun'Ichi

PY - 2011/1/15

Y1 - 2011/1/15

N2 - Three new Lycopodium alkaloids, lyconadins D (1) and E (2), and complanadine E (3), were isolated from the club moss Lycopodium complanatum. Lyconadin D (1) was the first example of fastigiatine-type alkaloid isolated from Lycopodium complanatum. The structures and relative stereochemistry of 1-3 were elucidated on the basis of spectroscopic data. Complanadine E (3) enhanced mRNA expression for NGF.

AB - Three new Lycopodium alkaloids, lyconadins D (1) and E (2), and complanadine E (3), were isolated from the club moss Lycopodium complanatum. Lyconadin D (1) was the first example of fastigiatine-type alkaloid isolated from Lycopodium complanatum. The structures and relative stereochemistry of 1-3 were elucidated on the basis of spectroscopic data. Complanadine E (3) enhanced mRNA expression for NGF.

KW - Complanadine E

KW - Lyconadin D

KW - Lyconadin E

KW - Lycopodium alkaloids

KW - Lycopodium complanatum

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Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum

Abstract

Keywords

ASJC Scopus subject areas

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