Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum

Kan'Ichiro Ishiuchi, Takaaki Kubota, Haruaki Ishiyama, Shigeki Hayashi, Toshiro Shibata, Koichiro Mori, Yutaro Obara, Norimichi Nakahata, Jun'Ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Three new Lycopodium alkaloids, lyconadins D (1) and E (2), and complanadine E (3), were isolated from the club moss Lycopodium complanatum. Lyconadin D (1) was the first example of fastigiatine-type alkaloid isolated from Lycopodium complanatum. The structures and relative stereochemistry of 1-3 were elucidated on the basis of spectroscopic data. Complanadine E (3) enhanced mRNA expression for NGF.

Original languageEnglish
Pages (from-to)749-753
Number of pages5
JournalBioorganic and Medicinal Chemistry
Volume19
Issue number2
DOIs
Publication statusPublished - Jan 15 2011
Externally publishedYes

Keywords

  • Complanadine E
  • Lyconadin D
  • Lyconadin E
  • Lycopodium alkaloids
  • Lycopodium complanatum

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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