Conformationally restricted heterocyclic analogs of carba-T0901317, a liver X receptor (LXR) antagonist, were prepared via the palladium catalized cyclization reaction as a key step. In vitro transactivation assay revealed that the structural modification altered the nature of the activity from LXR-agonistic to LXR-antagonistic.
|Number of pages||6|
|Publication status||Published - 2008|
ASJC Scopus subject areas
- Analytical Chemistry
- Organic Chemistry