Lung transplantation from uncontrolled and controlled donation after circulatory death: similar outcomes to brain death donors

Jose Luis Campo-Cañaveral de la Cruz, Silvana Crowley Carrasco, Shin Tanaka, Alejandra Romero Román, Lucas Hoyos Mejía, Mariana Gil Barturen, Álvaro Sánchez Calle, Christian García Fadul, Myriam Aguilar Pérez, Marina Pérez Redondo, Jose Manuel Naranjo Gómez, Ana Royuela, Mar Córdoba Peláez, Andrés Varela de Ugarte, David Gómez de Antonio

Research output: Contribution to journalArticlepeer-review

Abstract

Controlled donation after circulatory death donors (cDCD) are becoming a frequent source of lungs grafts worldwide. Conversely, lung transplantations (LTx) from uncontrolled donors (uDCD) are sporadically reported. We aimed to review our institutional experience using both uDCD and cDCD and compare to LTx from brain death donors (DBD). This is a retrospective analysis of all LTx performed between January 2013 and December 2019 in our institution. Donor and recipient characteristics were collected and univariate, multivariate and survival analyses were carried out comparing the three cohorts of donors. A total of 239 (84.7%) LTx were performed from DBD, 29 (10.3%) from cDCD and 14 (5%) from uDCD. There were no statistically significant differences in primary graft dysfunction grade 3 at 72 h, 30- and 90-day mortality, need for extracorporeal membrane oxygenation after procedure, ICU and hospital length of stay, airway complications, CLAD incidence or survival at 1 and 3 years after transplant (DBD: 87.1% and 78.1%; cDCD: 89.7% and 89.7%; uDCD: 85.7% and 85.7% respectively; P = 0.42). Short- and mid-term outcomes are comparable between the three types of donors. These findings may encourage and reinforce all types of donation after circulatory death programmes as a valid and growing source of suitable organs for transplantation.

Original languageEnglish
JournalTransplant International
DOIs
Publication statusAccepted/In press - 2021
Externally publishedYes

Keywords

  • brain death donors
  • controlled donors after circulatory death
  • early mortality
  • lung transplantation
  • overall survival
  • uncontrolled donors after circulatory death

ASJC Scopus subject areas

  • Transplantation

Fingerprint

Dive into the research topics of 'Lung transplantation from uncontrolled and controlled donation after circulatory death: similar outcomes to brain death donors'. Together they form a unique fingerprint.

Cite this