Lung transplantation for diffuse panbronchiolitis

5 cases from a single centre

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Diffuse panbronchiolitis is a rare complex genetic disease predominantly affecting East Asians, and is characterized by chronic inflammation of the respiratory bronchioles and sinobronchial infection. Although long-term macrolide therapy has been shown to significantly improve the survival in patients with diffuse panbronchiolitis, some patients continue to deteriorate, eventually requiring lung transplantation. However, lung transplantation for diffuse panbronchiolitis has rarely been reported and the outcome in these patients remains unknown. We describe our experience of lung transplantation for diffuse panbronchiolitis. A total of 5 patients received long-term macrolide therapy and had airway colonization by Pseudomonas aeruginosa preoperatively. Three patients had undergone sinus surgery for chronic rhinosinusitis before the transplantation. Bilateral cadaveric lung transplantation was performed in 4 patients, and living-donor lung transplantation in 1. After the lung transplantation, 1 patient developed an A3 acute rejection episode; however, none of the recipients developed severe pneumonia or any fatal infections. One recipient developed chronic lung allograft dysfunction 3 years after the transplantation; however, none developed recurrence of diffuse panbronchiolitis. All of the 5 patients were still surviving after a median follow-up period of 4.9 years (3.7-12.3 years). Lung transplantation is a viable option for the treatment of progressive diffuse panbronchiolitis resistant to long-term macrolide therapy.

Original languageEnglish
Pages (from-to)679-681
Number of pages3
JournalInteractive Cardiovascular and Thoracic Surgery
Volume22
Issue number5
DOIs
Publication statusPublished - May 1 2016

Fingerprint

Lung Transplantation
Macrolides
Transplantation
Bronchioles
Inborn Genetic Diseases
Living Donors
Therapeutics
Infection
Diffuse panbronchiolitis
Pseudomonas aeruginosa
Allografts
Pneumonia
Inflammation
Recurrence
Lung
Survival

Keywords

  • Bronchiolitis obliterans
  • Lung infection
  • Lung transplantation
  • Outcomes
  • Recurrence
  • Rejection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Lung transplantation for diffuse panbronchiolitis : 5 cases from a single centre. / Sugimoto, Seiichiro; Miyoshi, Kentaroh; Yamane, Masaomi; Oto, Takahiro.

In: Interactive Cardiovascular and Thoracic Surgery, Vol. 22, No. 5, 01.05.2016, p. 679-681.

Research output: Contribution to journalArticle

@article{1d0ba429c446413eaf94fc0bbdd7aa01,
title = "Lung transplantation for diffuse panbronchiolitis: 5 cases from a single centre",
abstract = "Diffuse panbronchiolitis is a rare complex genetic disease predominantly affecting East Asians, and is characterized by chronic inflammation of the respiratory bronchioles and sinobronchial infection. Although long-term macrolide therapy has been shown to significantly improve the survival in patients with diffuse panbronchiolitis, some patients continue to deteriorate, eventually requiring lung transplantation. However, lung transplantation for diffuse panbronchiolitis has rarely been reported and the outcome in these patients remains unknown. We describe our experience of lung transplantation for diffuse panbronchiolitis. A total of 5 patients received long-term macrolide therapy and had airway colonization by Pseudomonas aeruginosa preoperatively. Three patients had undergone sinus surgery for chronic rhinosinusitis before the transplantation. Bilateral cadaveric lung transplantation was performed in 4 patients, and living-donor lung transplantation in 1. After the lung transplantation, 1 patient developed an A3 acute rejection episode; however, none of the recipients developed severe pneumonia or any fatal infections. One recipient developed chronic lung allograft dysfunction 3 years after the transplantation; however, none developed recurrence of diffuse panbronchiolitis. All of the 5 patients were still surviving after a median follow-up period of 4.9 years (3.7-12.3 years). Lung transplantation is a viable option for the treatment of progressive diffuse panbronchiolitis resistant to long-term macrolide therapy.",
keywords = "Bronchiolitis obliterans, Lung infection, Lung transplantation, Outcomes, Recurrence, Rejection",
author = "Seiichiro Sugimoto and Kentaroh Miyoshi and Masaomi Yamane and Takahiro Oto",
year = "2016",
month = "5",
day = "1",
doi = "10.1093/icvts/ivw008",
language = "English",
volume = "22",
pages = "679--681",
journal = "Interactive Cardiovascular and Thoracic Surgery",
issn = "1569-9293",
publisher = "European Association for Cardio-Thoracic Surgery",
number = "5",

}

TY - JOUR

T1 - Lung transplantation for diffuse panbronchiolitis

T2 - 5 cases from a single centre

AU - Sugimoto, Seiichiro

AU - Miyoshi, Kentaroh

AU - Yamane, Masaomi

AU - Oto, Takahiro

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Diffuse panbronchiolitis is a rare complex genetic disease predominantly affecting East Asians, and is characterized by chronic inflammation of the respiratory bronchioles and sinobronchial infection. Although long-term macrolide therapy has been shown to significantly improve the survival in patients with diffuse panbronchiolitis, some patients continue to deteriorate, eventually requiring lung transplantation. However, lung transplantation for diffuse panbronchiolitis has rarely been reported and the outcome in these patients remains unknown. We describe our experience of lung transplantation for diffuse panbronchiolitis. A total of 5 patients received long-term macrolide therapy and had airway colonization by Pseudomonas aeruginosa preoperatively. Three patients had undergone sinus surgery for chronic rhinosinusitis before the transplantation. Bilateral cadaveric lung transplantation was performed in 4 patients, and living-donor lung transplantation in 1. After the lung transplantation, 1 patient developed an A3 acute rejection episode; however, none of the recipients developed severe pneumonia or any fatal infections. One recipient developed chronic lung allograft dysfunction 3 years after the transplantation; however, none developed recurrence of diffuse panbronchiolitis. All of the 5 patients were still surviving after a median follow-up period of 4.9 years (3.7-12.3 years). Lung transplantation is a viable option for the treatment of progressive diffuse panbronchiolitis resistant to long-term macrolide therapy.

AB - Diffuse panbronchiolitis is a rare complex genetic disease predominantly affecting East Asians, and is characterized by chronic inflammation of the respiratory bronchioles and sinobronchial infection. Although long-term macrolide therapy has been shown to significantly improve the survival in patients with diffuse panbronchiolitis, some patients continue to deteriorate, eventually requiring lung transplantation. However, lung transplantation for diffuse panbronchiolitis has rarely been reported and the outcome in these patients remains unknown. We describe our experience of lung transplantation for diffuse panbronchiolitis. A total of 5 patients received long-term macrolide therapy and had airway colonization by Pseudomonas aeruginosa preoperatively. Three patients had undergone sinus surgery for chronic rhinosinusitis before the transplantation. Bilateral cadaveric lung transplantation was performed in 4 patients, and living-donor lung transplantation in 1. After the lung transplantation, 1 patient developed an A3 acute rejection episode; however, none of the recipients developed severe pneumonia or any fatal infections. One recipient developed chronic lung allograft dysfunction 3 years after the transplantation; however, none developed recurrence of diffuse panbronchiolitis. All of the 5 patients were still surviving after a median follow-up period of 4.9 years (3.7-12.3 years). Lung transplantation is a viable option for the treatment of progressive diffuse panbronchiolitis resistant to long-term macrolide therapy.

KW - Bronchiolitis obliterans

KW - Lung infection

KW - Lung transplantation

KW - Outcomes

KW - Recurrence

KW - Rejection

UR - http://www.scopus.com/inward/record.url?scp=84964969761&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964969761&partnerID=8YFLogxK

U2 - 10.1093/icvts/ivw008

DO - 10.1093/icvts/ivw008

M3 - Article

VL - 22

SP - 679

EP - 681

JO - Interactive Cardiovascular and Thoracic Surgery

JF - Interactive Cardiovascular and Thoracic Surgery

SN - 1569-9293

IS - 5

ER -