Luminal acidification of diverse organelles by V-ATPase in animal cells

Masamitsu Futai, Toshihiko Oka, Ge Hong Sun-Wada, Yoshinori Moriyama, Hiroshi Kanazawa, Yoh Wada

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Eukaryotic cells contain organelles bounded by a single membrane in the cytoplasm. These organelles have differentiated to carry out various functions in the pathways of endocytosis and exocytosis. Their lumina are acidic, with pH ranging from 4.5 to 6.5. This-article describes recent studies on these animal cell organelles focusing on (1) the primary ... proton pump (vacuolar-type H+-ATPase) and (2) the functions of the organelle luminal acidity, we also discuss similarities and differences between vacuolar-type H+-ATPase and F-type ATPase. Our own studies and interests are emphasized.

Original languageEnglish
Pages (from-to)107-116
Number of pages10
JournalJournal of Experimental Biology
Volume203
Issue number1
Publication statusPublished - Jan 1 2000

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Keywords

  • ATPase
  • Endomembrane organelle
  • Organelle
  • Proton pump
  • V-ATPase
  • Vacuolar-type ATPase

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Aquatic Science
  • Animal Science and Zoology
  • Molecular Biology
  • Insect Science

Cite this

Futai, M., Oka, T., Sun-Wada, G. H., Moriyama, Y., Kanazawa, H., & Wada, Y. (2000). Luminal acidification of diverse organelles by V-ATPase in animal cells. Journal of Experimental Biology, 203(1), 107-116.