Low-temperature method for enhancement of enantioselectivity in the lipase-catalyzed kinetic resolutions of solketal and some chiral alcohols

Takashi Sakai, Tetsuo Kishimoto, Yukie Tanaka, Tadashi Ema, Masanori Utaka

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Low-temperature method (-40 °C at best) for enhancement of the enantioselectivity in a lipase-catalyzed transesterification was proved to be widely applicable to primary and secondary alcohols and enabled theoretical prediction of the course of enhancement of the enantioselectivity physicochemically.

Original languageEnglish
Pages (from-to)7881-7884
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number43
DOIs
Publication statusPublished - Oct 22 1998

Keywords

  • Acylation
  • Enantiospecificity
  • Enzymes and enzyme reactions
  • Resolution

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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