Low incidence of acute GVHD in patients transplanted with marrow from HLA-A-A,B,DR-compatible unrelated donors among Japanese

Y. Morishima, Y. Kodera, N. Hirabayashi, M. Tanimoto, T. Matsuyama, K. Horibe, H. Ohta, S. Mizuno, Y. Morishita, T. Yamauchi, H. Yamada, R. Sobue, S. Shiobara, S. Minami, S. Goto, K. Ogawa, N. Hamajima, H. Saito

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

To prevent GVHD in BMT from unrelated donors, the matching of HLA between patient and donor is crucial. The appearance of acute GVHD was studied in 51 patients with hematological malignancies who were transplanted with non-T cell purged marrow from HLA-A,B and DR compatible unrelated donors with the assistance of the Tokai Marrow Donor Bank of Nagoya, Japan. Probability of grade II-IV acute GVHD was 32.0% and of grade II-IV acute GVHD was 17.0%. HLA-class II antigen compatibility showed a good correlation with the occurrence of acute GVHD. When the percentage relative response (RR) of MLC between patient and donor (GVHD vector) was ≤ 5, grade II-IV acute GVHD was found in only 7.7% of patients (n = 16) and no severe grade III-IV GVHD occurred. Among patients with 6-10 %RR (n = 10), 25.9% showed grade II-TV GVHD and 14.3% grade III-IV GVHD. Among patients with ≥ 11%RR (n = 20), however, the incidence of grade II-IV acute GVHD reached 51.8% and that of grade III-IV acute GVHD 36.2%. These reactivities of MLC reflected the compatibility of HLA-DRB1 and DPB1. The fact that the incidence of acute GVHD in MTs from HLA-A,B,DR compatible Japanese pairs was found to be lower than in the USA may be due to less diversity of the genetic background in Japan.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalBone Marrow Transplantation
Volume15
Issue number2
Publication statusPublished - Jan 1 1995

Keywords

  • Acute GVHD
  • HLA compatible
  • Incidence
  • Japanese
  • Unrelated donor

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Morishima, Y., Kodera, Y., Hirabayashi, N., Tanimoto, M., Matsuyama, T., Horibe, K., Ohta, H., Mizuno, S., Morishita, Y., Yamauchi, T., Yamada, H., Sobue, R., Shiobara, S., Minami, S., Goto, S., Ogawa, K., Hamajima, N., & Saito, H. (1995). Low incidence of acute GVHD in patients transplanted with marrow from HLA-A-A,B,DR-compatible unrelated donors among Japanese. Bone Marrow Transplantation, 15(2), 235-239.