Low incidence of acute graft-versus-host disease by the administration of methotrexate and cyclosporine in Japanese leukemia patients after bone marrow transplantation from human leukocyte antigen compatible siblings; possible role of genetic homogeneity

Y. Morishima, Y. Morishita, M. Tanimoto, R. Ohno, H. Saito, K. Horibe, N. Hamajima, K. Naito, K. Yamada, S. Yokomaku, N. Hirabayashi, H. Yamada, Y. Nakaide, S. Kojima, S. Minami, K. Matsuyama, Y. Kodera

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Abstract

Japanese patients with leukemia who received bone marrow from human leukocyte antigen (HLA)-compatible siblings had a low incidence of acute graft-versus-host disease (GVHD). Twenty-five (21%) of 120 patients developed moderate (grade II) to severe (grades III to IV) acute GVHD. Severe GVHD was only seen in patients older than 20 years of age. It is also notable that only 2 (5%) of 39 patients who received the combination of methotrexate and cyclosporine (MTX/CSP) for the prevention of GVHD developed grade II acute GVHD, and none developed grades III to IV acute GVHD. Thirteen (30%) of 44 patients receiving MTX alone and 10 (27%) of 37 patients receiving CSP alone developed grades II to IV acute GVHD. Multivariate life-table analysis indicated that the prophylaxis by MTX/CSP was the risk factor for the low incidence of grades II to IV acute GVHD. Compared with the reported incidence of acute GVHD in the patients of the United States, lower incidence of acute GVHD in Japanese BMT patients might be attributable to a lesser degree of genetic diversity in histocompatibility antigens among Japanese.

Original languageEnglish
Pages (from-to)2252-2256
Number of pages5
JournalBlood
Volume74
Issue number6
Publication statusPublished - 1989
Externally publishedYes

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Graft vs Host Disease
HLA Antigens
Bone Marrow Transplantation
Methotrexate
Grafts
Cyclosporine
Siblings
Bone
Leukemia
Incidence
Histocompatibility Antigens
Life Tables
Bone Marrow

ASJC Scopus subject areas

  • Hematology

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Low incidence of acute graft-versus-host disease by the administration of methotrexate and cyclosporine in Japanese leukemia patients after bone marrow transplantation from human leukocyte antigen compatible siblings; possible role of genetic homogeneity. / Morishima, Y.; Morishita, Y.; Tanimoto, M.; Ohno, R.; Saito, H.; Horibe, K.; Hamajima, N.; Naito, K.; Yamada, K.; Yokomaku, S.; Hirabayashi, N.; Yamada, H.; Nakaide, Y.; Kojima, S.; Minami, S.; Matsuyama, K.; Kodera, Y.

In: Blood, Vol. 74, No. 6, 1989, p. 2252-2256.

Research output: Contribution to journalArticle

Morishima, Y, Morishita, Y, Tanimoto, M, Ohno, R, Saito, H, Horibe, K, Hamajima, N, Naito, K, Yamada, K, Yokomaku, S, Hirabayashi, N, Yamada, H, Nakaide, Y, Kojima, S, Minami, S, Matsuyama, K & Kodera, Y 1989, 'Low incidence of acute graft-versus-host disease by the administration of methotrexate and cyclosporine in Japanese leukemia patients after bone marrow transplantation from human leukocyte antigen compatible siblings; possible role of genetic homogeneity', Blood, vol. 74, no. 6, pp. 2252-2256.
Morishima, Y. ; Morishita, Y. ; Tanimoto, M. ; Ohno, R. ; Saito, H. ; Horibe, K. ; Hamajima, N. ; Naito, K. ; Yamada, K. ; Yokomaku, S. ; Hirabayashi, N. ; Yamada, H. ; Nakaide, Y. ; Kojima, S. ; Minami, S. ; Matsuyama, K. ; Kodera, Y. / Low incidence of acute graft-versus-host disease by the administration of methotrexate and cyclosporine in Japanese leukemia patients after bone marrow transplantation from human leukocyte antigen compatible siblings; possible role of genetic homogeneity. In: Blood. 1989 ; Vol. 74, No. 6. pp. 2252-2256.
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abstract = "Japanese patients with leukemia who received bone marrow from human leukocyte antigen (HLA)-compatible siblings had a low incidence of acute graft-versus-host disease (GVHD). Twenty-five (21{\%}) of 120 patients developed moderate (grade II) to severe (grades III to IV) acute GVHD. Severe GVHD was only seen in patients older than 20 years of age. It is also notable that only 2 (5{\%}) of 39 patients who received the combination of methotrexate and cyclosporine (MTX/CSP) for the prevention of GVHD developed grade II acute GVHD, and none developed grades III to IV acute GVHD. Thirteen (30{\%}) of 44 patients receiving MTX alone and 10 (27{\%}) of 37 patients receiving CSP alone developed grades II to IV acute GVHD. Multivariate life-table analysis indicated that the prophylaxis by MTX/CSP was the risk factor for the low incidence of grades II to IV acute GVHD. Compared with the reported incidence of acute GVHD in the patients of the United States, lower incidence of acute GVHD in Japanese BMT patients might be attributable to a lesser degree of genetic diversity in histocompatibility antigens among Japanese.",
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T1 - Low incidence of acute graft-versus-host disease by the administration of methotrexate and cyclosporine in Japanese leukemia patients after bone marrow transplantation from human leukocyte antigen compatible siblings; possible role of genetic homogeneity

AU - Morishima, Y.

AU - Morishita, Y.

AU - Tanimoto, M.

AU - Ohno, R.

AU - Saito, H.

AU - Horibe, K.

AU - Hamajima, N.

AU - Naito, K.

AU - Yamada, K.

AU - Yokomaku, S.

AU - Hirabayashi, N.

AU - Yamada, H.

AU - Nakaide, Y.

AU - Kojima, S.

AU - Minami, S.

AU - Matsuyama, K.

AU - Kodera, Y.

PY - 1989

Y1 - 1989

N2 - Japanese patients with leukemia who received bone marrow from human leukocyte antigen (HLA)-compatible siblings had a low incidence of acute graft-versus-host disease (GVHD). Twenty-five (21%) of 120 patients developed moderate (grade II) to severe (grades III to IV) acute GVHD. Severe GVHD was only seen in patients older than 20 years of age. It is also notable that only 2 (5%) of 39 patients who received the combination of methotrexate and cyclosporine (MTX/CSP) for the prevention of GVHD developed grade II acute GVHD, and none developed grades III to IV acute GVHD. Thirteen (30%) of 44 patients receiving MTX alone and 10 (27%) of 37 patients receiving CSP alone developed grades II to IV acute GVHD. Multivariate life-table analysis indicated that the prophylaxis by MTX/CSP was the risk factor for the low incidence of grades II to IV acute GVHD. Compared with the reported incidence of acute GVHD in the patients of the United States, lower incidence of acute GVHD in Japanese BMT patients might be attributable to a lesser degree of genetic diversity in histocompatibility antigens among Japanese.

AB - Japanese patients with leukemia who received bone marrow from human leukocyte antigen (HLA)-compatible siblings had a low incidence of acute graft-versus-host disease (GVHD). Twenty-five (21%) of 120 patients developed moderate (grade II) to severe (grades III to IV) acute GVHD. Severe GVHD was only seen in patients older than 20 years of age. It is also notable that only 2 (5%) of 39 patients who received the combination of methotrexate and cyclosporine (MTX/CSP) for the prevention of GVHD developed grade II acute GVHD, and none developed grades III to IV acute GVHD. Thirteen (30%) of 44 patients receiving MTX alone and 10 (27%) of 37 patients receiving CSP alone developed grades II to IV acute GVHD. Multivariate life-table analysis indicated that the prophylaxis by MTX/CSP was the risk factor for the low incidence of grades II to IV acute GVHD. Compared with the reported incidence of acute GVHD in the patients of the United States, lower incidence of acute GVHD in Japanese BMT patients might be attributable to a lesser degree of genetic diversity in histocompatibility antigens among Japanese.

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