Abstract
Background: Insulin resistance is strongly associated with metabolic syndrome (MetS), but it is not known how this association is influenced by the autonomic nervous system, which controls insulin secretion. Methods and Results: The subjects were 2,016 individuals aged 30-79 years enrolled between 2009 and 2012. MetS was determined using the harmonized MetS definition, which includes waist circumference, blood pressure, triglycerides, high-density lipoprotein cholesterol, and fasting glucose. The homeostasis model assessment index for insulin resistance (HOMA-IR) and Gutt’s insulin sensitivity index (ISI) were calculated based on fasting and 2 h-post-load glucose and insulin concentrations in a 75-g oral glucose tolerance test. The 5-min heart rate variability (HRV) was evaluated using time-domain indices of standard deviations of NN intervals (SDNN) and root mean square of successive differences (RMSSD). Power spectral analysis yielded frequency-domain measures for HRV: high-frequency (HF) power, low-frequency (LF) power and LF/HF. Multivariable adjusted logistic models showed that the highest quartiles for SDNN, RMSSD, LF, and HF vs. the lowest quartiles had a significant association with MetS. RMSSD, HF, and LF/HF remained significantly associated with MetS after adjustment for HOMA-IR (or ISI). Additive interactions between the levels of high LF/HF and high HOMA-IR (or low ISI) were significantly positive. Conclusions: Sympathovagal imbalance as evidenced by low HF and high LF/HF modified the association of insulin resistance or low insulin sensitivity with MetS.
| Original language | English |
|---|---|
| Pages (from-to) | 1447-1453 |
| Number of pages | 7 |
| Journal | Circulation Journal |
| Volume | 81 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2017 |
Fingerprint
Keywords
- Epidemiology
- Heart rate variability
- Insulin sensitivity
- Metabolic syndrome
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Low heart rate variability and sympathetic dominance modifies the association between insulin resistance and metabolic syndrome : ― The Toon Health Study ―. / Saito, Isao; Maruyama, Koutatsu; Eguchi, Eri; Kato, Tadahiro; Kawamura, Ryoichi; Takata, Yasunori; Onuma, Hiroshi; Osawa, Haruhiko; Tanigawa, Takeshi.
In: Circulation Journal, Vol. 81, No. 10, 2017, p. 1447-1453.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Low heart rate variability and sympathetic dominance modifies the association between insulin resistance and metabolic syndrome
T2 - ― The Toon Health Study ―
AU - Saito, Isao
AU - Maruyama, Koutatsu
AU - Eguchi, Eri
AU - Kato, Tadahiro
AU - Kawamura, Ryoichi
AU - Takata, Yasunori
AU - Onuma, Hiroshi
AU - Osawa, Haruhiko
AU - Tanigawa, Takeshi
PY - 2017
Y1 - 2017
N2 - Background: Insulin resistance is strongly associated with metabolic syndrome (MetS), but it is not known how this association is influenced by the autonomic nervous system, which controls insulin secretion. Methods and Results: The subjects were 2,016 individuals aged 30-79 years enrolled between 2009 and 2012. MetS was determined using the harmonized MetS definition, which includes waist circumference, blood pressure, triglycerides, high-density lipoprotein cholesterol, and fasting glucose. The homeostasis model assessment index for insulin resistance (HOMA-IR) and Gutt’s insulin sensitivity index (ISI) were calculated based on fasting and 2 h-post-load glucose and insulin concentrations in a 75-g oral glucose tolerance test. The 5-min heart rate variability (HRV) was evaluated using time-domain indices of standard deviations of NN intervals (SDNN) and root mean square of successive differences (RMSSD). Power spectral analysis yielded frequency-domain measures for HRV: high-frequency (HF) power, low-frequency (LF) power and LF/HF. Multivariable adjusted logistic models showed that the highest quartiles for SDNN, RMSSD, LF, and HF vs. the lowest quartiles had a significant association with MetS. RMSSD, HF, and LF/HF remained significantly associated with MetS after adjustment for HOMA-IR (or ISI). Additive interactions between the levels of high LF/HF and high HOMA-IR (or low ISI) were significantly positive. Conclusions: Sympathovagal imbalance as evidenced by low HF and high LF/HF modified the association of insulin resistance or low insulin sensitivity with MetS.
AB - Background: Insulin resistance is strongly associated with metabolic syndrome (MetS), but it is not known how this association is influenced by the autonomic nervous system, which controls insulin secretion. Methods and Results: The subjects were 2,016 individuals aged 30-79 years enrolled between 2009 and 2012. MetS was determined using the harmonized MetS definition, which includes waist circumference, blood pressure, triglycerides, high-density lipoprotein cholesterol, and fasting glucose. The homeostasis model assessment index for insulin resistance (HOMA-IR) and Gutt’s insulin sensitivity index (ISI) were calculated based on fasting and 2 h-post-load glucose and insulin concentrations in a 75-g oral glucose tolerance test. The 5-min heart rate variability (HRV) was evaluated using time-domain indices of standard deviations of NN intervals (SDNN) and root mean square of successive differences (RMSSD). Power spectral analysis yielded frequency-domain measures for HRV: high-frequency (HF) power, low-frequency (LF) power and LF/HF. Multivariable adjusted logistic models showed that the highest quartiles for SDNN, RMSSD, LF, and HF vs. the lowest quartiles had a significant association with MetS. RMSSD, HF, and LF/HF remained significantly associated with MetS after adjustment for HOMA-IR (or ISI). Additive interactions between the levels of high LF/HF and high HOMA-IR (or low ISI) were significantly positive. Conclusions: Sympathovagal imbalance as evidenced by low HF and high LF/HF modified the association of insulin resistance or low insulin sensitivity with MetS.
KW - Epidemiology
KW - Heart rate variability
KW - Insulin sensitivity
KW - Metabolic syndrome
UR - http://www.scopus.com/inward/record.url?scp=85030117070&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85030117070&partnerID=8YFLogxK
U2 - 10.1253/circj.CJ-17-0192
DO - 10.1253/circj.CJ-17-0192
M3 - Article
C2 - 28566656
AN - SCOPUS:85030117070
VL - 81
SP - 1447
EP - 1453
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 10
ER -