TY - JOUR
T1 - Low heart rate variability and sympathetic dominance modifies the association between insulin resistance and metabolic syndrome
T2 - ― The Toon Health Study ―
AU - Saito, Isao
AU - Maruyama, Koutatsu
AU - Eguchi, Eri
AU - Kato, Tadahiro
AU - Kawamura, Ryoichi
AU - Takata, Yasunori
AU - Onuma, Hiroshi
AU - Osawa, Haruhiko
AU - Tanigawa, Takeshi
N1 - Funding Information:
This study was supported, in part, by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (Grants-in-Aid for Research B, no. 22390134 in 2010–2012 and 25293142 from 2013, Grants-in-Aid for Young Scientists (B), no. 25860443 and 25860441 from 2013, and Grant-in-Aid for Research C, no. 26460767) and Health and Labor Sciences Research Grants from the Ministry of Health, Welfare, and Labor, Japan (Comprehensive Research on Life-Style Related Diseases including Cardiovascular Diseases and Diabetes Mellitus, no. 201021038A in 2010–2012).
Publisher Copyright:
© 2017, Japanese Circulation Society. All rights reserved.
PY - 2017
Y1 - 2017
N2 - Background: Insulin resistance is strongly associated with metabolic syndrome (MetS), but it is not known how this association is influenced by the autonomic nervous system, which controls insulin secretion. Methods and Results: The subjects were 2,016 individuals aged 30-79 years enrolled between 2009 and 2012. MetS was determined using the harmonized MetS definition, which includes waist circumference, blood pressure, triglycerides, high-density lipoprotein cholesterol, and fasting glucose. The homeostasis model assessment index for insulin resistance (HOMA-IR) and Gutt’s insulin sensitivity index (ISI) were calculated based on fasting and 2 h-post-load glucose and insulin concentrations in a 75-g oral glucose tolerance test. The 5-min heart rate variability (HRV) was evaluated using time-domain indices of standard deviations of NN intervals (SDNN) and root mean square of successive differences (RMSSD). Power spectral analysis yielded frequency-domain measures for HRV: high-frequency (HF) power, low-frequency (LF) power and LF/HF. Multivariable adjusted logistic models showed that the highest quartiles for SDNN, RMSSD, LF, and HF vs. the lowest quartiles had a significant association with MetS. RMSSD, HF, and LF/HF remained significantly associated with MetS after adjustment for HOMA-IR (or ISI). Additive interactions between the levels of high LF/HF and high HOMA-IR (or low ISI) were significantly positive. Conclusions: Sympathovagal imbalance as evidenced by low HF and high LF/HF modified the association of insulin resistance or low insulin sensitivity with MetS.
AB - Background: Insulin resistance is strongly associated with metabolic syndrome (MetS), but it is not known how this association is influenced by the autonomic nervous system, which controls insulin secretion. Methods and Results: The subjects were 2,016 individuals aged 30-79 years enrolled between 2009 and 2012. MetS was determined using the harmonized MetS definition, which includes waist circumference, blood pressure, triglycerides, high-density lipoprotein cholesterol, and fasting glucose. The homeostasis model assessment index for insulin resistance (HOMA-IR) and Gutt’s insulin sensitivity index (ISI) were calculated based on fasting and 2 h-post-load glucose and insulin concentrations in a 75-g oral glucose tolerance test. The 5-min heart rate variability (HRV) was evaluated using time-domain indices of standard deviations of NN intervals (SDNN) and root mean square of successive differences (RMSSD). Power spectral analysis yielded frequency-domain measures for HRV: high-frequency (HF) power, low-frequency (LF) power and LF/HF. Multivariable adjusted logistic models showed that the highest quartiles for SDNN, RMSSD, LF, and HF vs. the lowest quartiles had a significant association with MetS. RMSSD, HF, and LF/HF remained significantly associated with MetS after adjustment for HOMA-IR (or ISI). Additive interactions between the levels of high LF/HF and high HOMA-IR (or low ISI) were significantly positive. Conclusions: Sympathovagal imbalance as evidenced by low HF and high LF/HF modified the association of insulin resistance or low insulin sensitivity with MetS.
KW - Epidemiology
KW - Heart rate variability
KW - Insulin sensitivity
KW - Metabolic syndrome
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U2 - 10.1253/circj.CJ-17-0192
DO - 10.1253/circj.CJ-17-0192
M3 - Article
C2 - 28566656
AN - SCOPUS:85030117070
VL - 81
SP - 1447
EP - 1453
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 10
ER -