Low-grade B-cell lymphoma presenting primarily in the bone marrow

Kayoko Iwatani, Katsuyoshi Takata, Yasuharu Sato, Tomoko Miyata-Takata, Noriko Iwaki, Wei Cui, Seiko Sawada-Kitamura, Hiroshi Sonobe, Maiko Tamura, Katsuhiko Saito, Katsuya Miyatani, Rie Yamasaki, Ichiro Yamadori, Nobuharu Fujii, Yasushi Terasaki, Yoshinobu Maeda, Mitsune Tanimoto, Naoya Nakamura, Tadashi Yoshino

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Abstract

Cases of low-grade B-cell lymphoma presenting primarily in the bone marrow are rare, and its clinicopathology remains unclear. We retrospectively examined patients with low-grade B-cell lymphoma presenting primarily in the bone marrow. Fourteen patients met the inclusion criteria, including 5 with lymphoplasmacytic lymphoma (LPL), 3 with chronic lymphocytic leukemia/small lymphocytic lymphoma, 2 with follicular lymphoma (FL), and 4 with low-grade B-cell lymphoma not otherwise specified (LGBCL-NOS). The median age was 69.5 years (range, 42-89 years), and a slight male predominance was noted (9 men and 5 women, 1.8: 1). Immunohistochemically, all cases were positive for CD20. One case was positive for CD138. Both cases of FL were positive for CD10 and B-cell lymphoma 2 (BCL-2), and immunoglobulin heavy locus (IgH)/B-cell lymphoma 2 rearrangement was observed by fluorescence in situ hybridization. The myeloid differentiation primary response gene (88) leucine to proline mutation was observed in 3 of 5 LPL, 1 of 2 FL, and 2 of 4 LGBCL-NOS patients. Paraproteinemia was observed in 10 patients; IgM and IgG paraproteinemia were observed in 6 and 3 patients, respectively. In this patient series, 3 patients had died at a median follow-up of 36.5 months; the cause of death of 1 LPL patient was malignant lymphoma itself. Thus, low-grade B-cell lymphoma presenting primarily in the bone marrow has various subtypes, and approximately one-third of the patients had LGBCL-NOS. The immunophenotypic features and myeloid differentiation primary response gene (88) leucine to proline mutation data of LGBCL-NOS suggested that some cases present with characteristics similar to those of LPL or marginal zone lymphoma.

Original languageEnglish
Pages (from-to)1379-1387
Number of pages9
JournalHuman Pathology
Volume45
Issue number7
DOIs
Publication statusPublished - Jul 2014

Keywords

  • Bone marrow
  • LGBCL-NOS
  • Low-grade B cell lymphoma
  • MYD88

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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  • Cite this

    Iwatani, K., Takata, K., Sato, Y., Miyata-Takata, T., Iwaki, N., Cui, W., Sawada-Kitamura, S., Sonobe, H., Tamura, M., Saito, K., Miyatani, K., Yamasaki, R., Yamadori, I., Fujii, N., Terasaki, Y., Maeda, Y., Tanimoto, M., Nakamura, N., & Yoshino, T. (2014). Low-grade B-cell lymphoma presenting primarily in the bone marrow. Human Pathology, 45(7), 1379-1387. https://doi.org/10.1016/j.humpath.2014.02.010