Low-Dose Trazodone for Delirium in Patients with Cancer Who Received Specialist Palliative Care: A Multicenter Prospective Study

Isseki Maeda, Shinichiro Inoue, Keiichi Uemura, Hitoshi Tanimukai, Yutaka Hatano, Naosuke Yokomichi, Koji Amano, Keita Tagami, Kazuhiro Yoshiuchi, Asao Ogawa, Satoru Iwase

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Clinical usefulness of trazodone for delirium in patients receiving palliative care is unclear. Objectives: To examine the safety and effectiveness of trazodone for delirium. Design: A secondary analysis of a multicenter prospective observational study. Setting/Subjects: The setting involves nine psycho-oncology consultation services and 14 inpatient palliative care units in Japan. Measurements: The measurement involves the Delirium Rating Scale (DRS) Revised-98 for effectiveness and the CTCAE (Common Terminology Criteria for Adverse Events) version 4 for safety assessments. Results: Thirty-eight patients enrolled the study. Mean age was 75 years. After three-day observation, the DRS total score (11.6 5.3 to 8.7 6.5 [difference-2.9, 95% confidence interval-5.3 to-0.5, p = 0.02]); sleep-wake cycle disturbance (p = 0.047), lability of affect (p 0.001), and motor agitation subscales (p & 0.001) were significantly decreased. The most frequent adverse event was somnolence (n = 9). Conclusions: Low-dose trazodone treatment was generally safe and may be effective in reducing delirium severity.

Original languageEnglish
Pages (from-to)914-918
Number of pages5
JournalJournal of Palliative Medicine
Volume24
Issue number6
DOIs
Publication statusPublished - Jun 2021
Externally publishedYes

Keywords

  • cancer
  • delirium
  • palliative care units
  • psycho-oncology
  • trazodone

ASJC Scopus subject areas

  • Nursing(all)
  • Anesthesiology and Pain Medicine

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