Low-attenuation areas of the lungs on high-resolution computed tomography in asthma

Fumihiro Mitsunobu, Takashi Mifune, Kozo Ashida, Yasuhiro Hosaki, Hirofumi Tsugeno, Makoto Okamoto, Seishi Harada, Yoshiro Tanizaki

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

To investigate the low-attenuation areas of the lungs (LAA) in asthma, we compared the mean lung density (MLD) and the LAA in 22 asthmatics (12 ex-smokers and 10 nonsmokers) and 13 patients with chronic obstructive pulmonary disease (COPD) by high-resolution computed tomography. The MLD and the relative area of the lung with attenuation values lower than -950 Hounsfield Units at full inspiration (inspiratory RA950) were significantly different in nonsmoking asthmatics compared to patients with COPD and asthmatics with a smoking history. The MLD and the RA950 correlated significantly with the FEV1 in all groups and with the DLco in patients with COPD and asthmatics with a smoking history but not in nonsmoking asthmatics. We concluded that the LAA in asthmatics with a smoking history indicates the presence of emphysema, but in nonsmoking asthmatics it reflects hyperinflation and nonemphysematous expiratory airflow limitation rather than emphysematous lesions.

Original languageEnglish
Pages (from-to)413-422
Number of pages10
JournalJournal of Asthma
Volume38
Issue number5
DOIs
Publication statusPublished - 2001

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Asthma
Tomography
Lung
Chronic Obstructive Pulmonary Disease
Smoking
History
Pulmonary Ventilation
Specific Gravity
Emphysema

Keywords

  • Asthma
  • DL
  • FEV
  • High-resolution computed tomography
  • Low-attenuation area

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Low-attenuation areas of the lungs on high-resolution computed tomography in asthma. / Mitsunobu, Fumihiro; Mifune, Takashi; Ashida, Kozo; Hosaki, Yasuhiro; Tsugeno, Hirofumi; Okamoto, Makoto; Harada, Seishi; Tanizaki, Yoshiro.

In: Journal of Asthma, Vol. 38, No. 5, 2001, p. 413-422.

Research output: Contribution to journalArticle

Mitsunobu, F, Mifune, T, Ashida, K, Hosaki, Y, Tsugeno, H, Okamoto, M, Harada, S & Tanizaki, Y 2001, 'Low-attenuation areas of the lungs on high-resolution computed tomography in asthma', Journal of Asthma, vol. 38, no. 5, pp. 413-422. https://doi.org/10.1081/JAS-100001496
Mitsunobu, Fumihiro ; Mifune, Takashi ; Ashida, Kozo ; Hosaki, Yasuhiro ; Tsugeno, Hirofumi ; Okamoto, Makoto ; Harada, Seishi ; Tanizaki, Yoshiro. / Low-attenuation areas of the lungs on high-resolution computed tomography in asthma. In: Journal of Asthma. 2001 ; Vol. 38, No. 5. pp. 413-422.
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