Abstract
Runt-related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial-mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC.
| Original language | English |
|---|---|
| Pages (from-to) | 745-749 |
| Number of pages | 5 |
| Journal | Journal of Cellular Biochemistry |
| Volume | 112 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2011 |
Fingerprint
Keywords
- Angiogenesis
- Apoptosis
- Epithelial-mesenchymal transition
- Tumor suppressor gene
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
Loss of runt-related transcription factor 3 causes development and progression of hepatocellular carcinoma. / Shiraha, Hidenori; Nishina, Shin Ichi; Yamamoto, Kazuhide.
In: Journal of Cellular Biochemistry, Vol. 112, No. 3, 03.2011, p. 745-749.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Loss of runt-related transcription factor 3 causes development and progression of hepatocellular carcinoma
AU - Shiraha, Hidenori
AU - Nishina, Shin Ichi
AU - Yamamoto, Kazuhide
PY - 2011/3
Y1 - 2011/3
N2 - Runt-related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial-mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC.
AB - Runt-related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial-mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC.
KW - Angiogenesis
KW - Apoptosis
KW - Epithelial-mesenchymal transition
KW - Tumor suppressor gene
UR - http://www.scopus.com/inward/record.url?scp=79951802134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951802134&partnerID=8YFLogxK
U2 - 10.1002/jcb.22973
DO - 10.1002/jcb.22973
M3 - Article
C2 - 21328447
AN - SCOPUS:79951802134
VL - 112
SP - 745
EP - 749
JO - Journal of Cellular Biochemistry
JF - Journal of Cellular Biochemistry
SN - 0730-2312
IS - 3
ER -