Loss of runt-related transcription factor 3 causes development and progression of hepatocellular carcinoma

Hidenori Shiraha; Shin Ichi Nishina; Kazuhide Yamamoto

doi:10.1002/jcb.22973

Loss of runt-related transcription factor 3 causes development and progression of hepatocellular carcinoma

Hidenori Shiraha, Shin Ichi Nishina, Kazuhide Yamamoto

University Hospital

Research output: Contribution to journal › Review article

24 Citations (Scopus)

Abstract

Runt-related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial-mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC.

Original language	English
Pages (from-to)	745-749
Number of pages	5
Journal	Journal of Cellular Biochemistry
Volume	112
Issue number	3
DOIs	https://doi.org/10.1002/jcb.22973
Publication status	Published - Mar 2011

Keywords

Angiogenesis
Apoptosis
Epithelial-mesenchymal transition
Tumor suppressor gene

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Loss of runt-related transcription factor 3 causes development and progression of hepatocellular carcinoma",

abstract = "Runt-related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial-mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC.",

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AU - Shiraha, Hidenori

AU - Nishina, Shin Ichi

AU - Yamamoto, Kazuhide

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N2 - Runt-related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial-mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC.

AB - Runt-related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial-mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC.

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KW - Apoptosis

KW - Epithelial-mesenchymal transition

KW - Tumor suppressor gene

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