Loss of runt-related transcription factor 3 causes development and progression of hepatocellular carcinoma

Hidenori Shiraha, Shin Ichi Nishina, Kazuhide Yamamoto

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Runt-related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial-mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC.

Original languageEnglish
Pages (from-to)745-749
Number of pages5
JournalJournal of Cellular Biochemistry
Volume112
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • Angiogenesis
  • Apoptosis
  • Epithelial-mesenchymal transition
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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