Loss of HLA haplotype in lung cancer cell lines: Implications for immunosurveillance of altered HLA class I/II phenotypes in lung cancer

Akio Hiraki, Toshihiko Kaneshige, Katsuyuki Kiura, Hiroshi Ueoka, Hiromichi Yamane, Motoyuki Tanaka, Mine Harada

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Loss of expression of HLA class I antigens has been demonstrated in a wide variety of tumors and is considered to be one of the mechanisms whereby tumors escape T-cell surveillance, Genomic DNA of MHC class I/II molecules in seven lung cancer cell lines was investigated and compared with that in peripheral blood mononuclear cells. In three cell lines, OU-LC-A1, OU-LC-A2, and OU-LC-AS1, a loss of HLA haplotype was observed. Aberrations of HLA class I/II in tumor cell lines should be considered when MHC-restricted phenomena in vitro models are assessed and clinical use of tumor vaccination in vivo is considered.

Original languageEnglish
Pages (from-to)933-936
Number of pages4
JournalClinical Cancer Research
Volume5
Issue number4
Publication statusPublished - Apr 1 1999

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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