TY - JOUR
T1 - Loss of heterozygosity at the 9p21-24 region and identification of BRM as a candidate tumor suppressor gene in head and neck squamous cell carcinoma
AU - Gunduz, Esra
AU - Gunduz, Mehmet
AU - Ali, Mahmoud Al Sheik
AU - Beder, Levent
AU - Tamamura, Ryo
AU - Katase, Naoki
AU - Tominaga, Susumu
AU - Yamanaka, Noboru
AU - Shimizu, Kenji
AU - Nagatsuka, Hitoshi
N1 - Funding Information:
This work was partially supported by grants-in-aid for scientific researches from the Ministry of Education, Culture, Sports, Science and Technology [19592109 (to H.N.), 17406027 (to N.N.), 20791337 (to R.T.)], Seed Innovation Research from Japan Science and Technology Agency (to M.G.), from Sumitomo Trust Haraguchi Memorial Cancer Research Promotion (to M.G.), and Astrazeneca Research Grant (to M.G.).
PY - 2009/7
Y1 - 2009/7
N2 - We have analyzed allelic loss of the short arm of chromosome 9 in 39 head and neck cancers using 13 polymorphic markers and found two deletions of hot spots at 9p21 and 9p24. Loss of heterozygosity was detected at least at one locus in 28 of 39 cases (71.8%). P16, a well-known tumor suppressor gene, is considered to be a target for deletion of the 9p21 region. However, novel frequent chromosomal deletion and a candidate tumor suppressor gene, BRM at the 9p24 region, were detected. Moreover, comparison of clinicopathological variables demonstrated that loss of heterozygosity at the BRM locus was associated with a worse prognosis.
AB - We have analyzed allelic loss of the short arm of chromosome 9 in 39 head and neck cancers using 13 polymorphic markers and found two deletions of hot spots at 9p21 and 9p24. Loss of heterozygosity was detected at least at one locus in 28 of 39 cases (71.8%). P16, a well-known tumor suppressor gene, is considered to be a target for deletion of the 9p21 region. However, novel frequent chromosomal deletion and a candidate tumor suppressor gene, BRM at the 9p24 region, were detected. Moreover, comparison of clinicopathological variables demonstrated that loss of heterozygosity at the BRM locus was associated with a worse prognosis.
KW - 9p24
KW - BRG1
KW - BRM
KW - Head and neck squamous cell carcinoma
KW - LOH
KW - Tumor suppressor gene
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U2 - 10.1080/07357900802563010
DO - 10.1080/07357900802563010
M3 - Article
C2 - 19488910
AN - SCOPUS:67649961615
SN - 0735-7907
VL - 27
SP - 661
EP - 668
JO - Cancer Investigation
JF - Cancer Investigation
IS - 6
ER -
