Loss of heterozygosity at the 9p21-24 region and identification of BRM as a candidate tumor suppressor gene in head and neck squamous cell carcinoma

Esra Gunduz, Mehmet Gunduz, Mahmoud Al Sheik Ali, Levent Beder, Ryo Tamamura, Naoki Katase, Susumu Tominaga, Noboru Yamanaka, Kenji Shimizu, Hitoshi Nagatsuka

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

We have analyzed allelic loss of the short arm of chromosome 9 in 39 head and neck cancers using 13 polymorphic markers and found two deletions of hot spots at 9p21 and 9p24. Loss of heterozygosity was detected at least at one locus in 28 of 39 cases (71.8%). P16, a well-known tumor suppressor gene, is considered to be a target for deletion of the 9p21 region. However, novel frequent chromosomal deletion and a candidate tumor suppressor gene, BRM at the 9p24 region, were detected. Moreover, comparison of clinicopathological variables demonstrated that loss of heterozygosity at the BRM locus was associated with a worse prognosis.

Original languageEnglish
Pages (from-to)661-668
Number of pages8
JournalCancer Investigation
Volume27
Issue number6
DOIs
Publication statusPublished - Jul 2009

Keywords

  • 9p24
  • BRG1
  • BRM
  • Head and neck squamous cell carcinoma
  • LOH
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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