Abstract
Purpose and methods: Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs. Results: Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival. Conclusions: The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.
| Original language | English |
|---|---|
| Pages (from-to) | 1267-1276 |
| Number of pages | 10 |
| Journal | Journal of Cancer Research and Clinical Oncology |
| Volume | 134 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2008 |
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Keywords
- 14q
- D14S67
- D14S995
- Head and neck squamous cell carcinoma
- Loss of heterozygosity
- Microsatellite marker
- Survival
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas. / Pehlivan, Davut; Gunduz, Esra; Gunduz, Mehmet; Nagatsuka, Hitoshi; Beder, Levent Bekir; Cengiz, Beyhan; Rivera, Rosario S.; Fukushima, Kunihiro; Palanduz, Sukru; Ozturk, Sukru; Yamanaka, Noboru; Shimizu, Kenji.
In: Journal of Cancer Research and Clinical Oncology, Vol. 134, No. 12, 12.2008, p. 1267-1276.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas
AU - Pehlivan, Davut
AU - Gunduz, Esra
AU - Gunduz, Mehmet
AU - Nagatsuka, Hitoshi
AU - Beder, Levent Bekir
AU - Cengiz, Beyhan
AU - Rivera, Rosario S.
AU - Fukushima, Kunihiro
AU - Palanduz, Sukru
AU - Ozturk, Sukru
AU - Yamanaka, Noboru
AU - Shimizu, Kenji
PY - 2008/12
Y1 - 2008/12
N2 - Purpose and methods: Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs. Results: Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival. Conclusions: The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.
AB - Purpose and methods: Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs. Results: Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival. Conclusions: The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.
KW - 14q
KW - D14S67
KW - D14S995
KW - Head and neck squamous cell carcinoma
KW - Loss of heterozygosity
KW - Microsatellite marker
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=54949157602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54949157602&partnerID=8YFLogxK
U2 - 10.1007/s00432-008-0423-1
DO - 10.1007/s00432-008-0423-1
M3 - Article
C2 - 18521630
AN - SCOPUS:54949157602
VL - 134
SP - 1267
EP - 1276
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
SN - 0171-5216
IS - 12
ER -