Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas

Davut Pehlivan; Esra Gunduz; Mehmet Gunduz; Hitoshi Nagatsuka; Levent Bekir Beder; Beyhan Cengiz; Rosario S. Rivera; Kunihiro Fukushima; Sukru Palanduz; Sukru Ozturk; Noboru Yamanaka; Kenji Shimizu

doi:10.1007/s00432-008-0423-1

Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas

Davut Pehlivan, Esra Gunduz, Mehmet Gunduz, Hitoshi Nagatsuka, Levent Bekir Beder, Beyhan Cengiz, Rosario S. Rivera, Kunihiro Fukushima, Sukru Palanduz, Sukru Ozturk, Noboru Yamanaka, Kenji Shimizu

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Purpose and methods: Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs. Results: Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival. Conclusions: The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.

Original language	English
Pages (from-to)	1267-1276
Number of pages	10
Journal	Journal of cancer research and clinical oncology
Volume	134
Issue number	12
DOIs	https://doi.org/10.1007/s00432-008-0423-1
Publication status	Published - Dec 2008

Keywords

14q
D14S67
D14S995
Head and neck squamous cell carcinoma
Loss of heterozygosity
Microsatellite marker
Survival

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00432-008-0423-1

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Pehlivan, D., Gunduz, E., Gunduz, M., Nagatsuka, H., Beder, L. B., Cengiz, B., Rivera, R. S., Fukushima, K., Palanduz, S., Ozturk, S., Yamanaka, N., & Shimizu, K. (2008). Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas. Journal of cancer research and clinical oncology, 134(12), 1267-1276. https://doi.org/10.1007/s00432-008-0423-1

Pehlivan, D, Gunduz, E, Gunduz, M, Nagatsuka, H, Beder, LB, Cengiz, B, Rivera, RS, Fukushima, K, Palanduz, S, Ozturk, S, Yamanaka, N & Shimizu, K 2008, 'Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas', Journal of cancer research and clinical oncology, vol. 134, no. 12, pp. 1267-1276. https://doi.org/10.1007/s00432-008-0423-1

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title = "Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas",

abstract = "Purpose and methods: Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs. Results: Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival. Conclusions: The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.",

keywords = "14q, D14S67, D14S995, Head and neck squamous cell carcinoma, Loss of heterozygosity, Microsatellite marker, Survival",

author = "Davut Pehlivan and Esra Gunduz and Mehmet Gunduz and Hitoshi Nagatsuka and Beder, {Levent Bekir} and Beyhan Cengiz and Rivera, {Rosario S.} and Kunihiro Fukushima and Sukru Palanduz and Sukru Ozturk and Noboru Yamanaka and Kenji Shimizu",

note = "Funding Information: Acknowledgments This work was partially supported by grants-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology [19592109 (to HN), 18-06262 (to EG), 17406027 (to NN)], Seed Innovation Research from Japan Science and Technology Agency (to MG), from Sumitomo Trust Haraguchi Memorial Cancer Research Promotion (to MG) and Astrazeneca Research Grant (to MG).",

year = "2008",

month = dec,

doi = "10.1007/s00432-008-0423-1",

language = "English",

volume = "134",

pages = "1267--1276",

journal = "Journal of Cancer Research and Clinical Oncology",

issn = "0171-5216",

publisher = "Springer Verlag",

number = "12",

}

TY - JOUR

T1 - Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas

AU - Pehlivan, Davut

AU - Gunduz, Esra

AU - Gunduz, Mehmet

AU - Nagatsuka, Hitoshi

AU - Beder, Levent Bekir

AU - Cengiz, Beyhan

AU - Rivera, Rosario S.

AU - Fukushima, Kunihiro

AU - Palanduz, Sukru

AU - Ozturk, Sukru

AU - Yamanaka, Noboru

AU - Shimizu, Kenji

N1 - Funding Information: Acknowledgments This work was partially supported by grants-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology [19592109 (to HN), 18-06262 (to EG), 17406027 (to NN)], Seed Innovation Research from Japan Science and Technology Agency (to MG), from Sumitomo Trust Haraguchi Memorial Cancer Research Promotion (to MG) and Astrazeneca Research Grant (to MG).

PY - 2008/12

Y1 - 2008/12

N2 - Purpose and methods: Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs. Results: Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival. Conclusions: The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.

AB - Purpose and methods: Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs. Results: Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival. Conclusions: The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.

KW - 14q

KW - D14S67

KW - D14S995

KW - Head and neck squamous cell carcinoma

KW - Loss of heterozygosity

KW - Microsatellite marker

KW - Survival

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U2 - 10.1007/s00432-008-0423-1

DO - 10.1007/s00432-008-0423-1

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C2 - 18521630

AN - SCOPUS:54949157602

VL - 134

SP - 1267

EP - 1276

JO - Journal of Cancer Research and Clinical Oncology

JF - Journal of Cancer Research and Clinical Oncology

SN - 0171-5216

IS - 12

ER -

Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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