Abstract
Purpose and methods: Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs. Results: Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival. Conclusions: The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.
Original language | English |
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Pages (from-to) | 1267-1276 |
Number of pages | 10 |
Journal | Journal of cancer research and clinical oncology |
Volume | 134 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2008 |
Keywords
- 14q
- D14S67
- D14S995
- Head and neck squamous cell carcinoma
- Loss of heterozygosity
- Microsatellite marker
- Survival
ASJC Scopus subject areas
- Oncology
- Cancer Research