Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas

Davut Pehlivan; Esra Gunduz; Mehmet Gunduz; Hitoshi Nagatsuka; Levent Bekir Beder; Beyhan Cengiz; Rosario S. Rivera; Kunihiro Fukushima; Sukru Palanduz; Sukru Ozturk; Noboru Yamanaka; Kenji Shimizu

doi:10.1007/s00432-008-0423-1

Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas

Davut Pehlivan, Esra Gunduz, Mehmet Gunduz, Hitoshi Nagatsuka, Levent Bekir Beder, Beyhan Cengiz, Rosario S. Rivera, Kunihiro Fukushima, Sukru Palanduz, Sukru Ozturk, Noboru Yamanaka, Kenji Shimizu

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Purpose and methods: Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs. Results: Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival. Conclusions: The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.

Original language	English
Pages (from-to)	1267-1276
Number of pages	10
Journal	Journal of cancer research and clinical oncology
Volume	134
Issue number	12
DOIs	https://doi.org/10.1007/s00432-008-0423-1
Publication status	Published - Dec 2008

Keywords

14q
D14S67
D14S995
Head and neck squamous cell carcinoma
Loss of heterozygosity
Microsatellite marker
Survival

ASJC Scopus subject areas

Oncology
Cancer Research

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Pehlivan, D., Gunduz, E., Gunduz, M., Nagatsuka, H., Beder, L. B., Cengiz, B., Rivera, R. S., Fukushima, K., Palanduz, S., Ozturk, S., Yamanaka, N., & Shimizu, K. (2008). Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas. Journal of cancer research and clinical oncology, 134(12), 1267-1276. https://doi.org/10.1007/s00432-008-0423-1

Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas. / Pehlivan, Davut; Gunduz, Esra; Gunduz, Mehmet; Nagatsuka, Hitoshi; Beder, Levent Bekir; Cengiz, Beyhan; Rivera, Rosario S.; Fukushima, Kunihiro; Palanduz, Sukru; Ozturk, Sukru; Yamanaka, Noboru; Shimizu, Kenji.

In: Journal of cancer research and clinical oncology, Vol. 134, No. 12, 12.2008, p. 1267-1276.

Research output: Contribution to journal › Article › peer-review

Pehlivan, D, Gunduz, E, Gunduz, M, Nagatsuka, H, Beder, LB, Cengiz, B, Rivera, RS, Fukushima, K, Palanduz, S, Ozturk, S, Yamanaka, N & Shimizu, K 2008, 'Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas', Journal of cancer research and clinical oncology, vol. 134, no. 12, pp. 1267-1276. https://doi.org/10.1007/s00432-008-0423-1

Pehlivan, Davut ; Gunduz, Esra ; Gunduz, Mehmet ; Nagatsuka, Hitoshi ; Beder, Levent Bekir ; Cengiz, Beyhan ; Rivera, Rosario S. ; Fukushima, Kunihiro ; Palanduz, Sukru ; Ozturk, Sukru ; Yamanaka, Noboru ; Shimizu, Kenji. / Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas. In: Journal of cancer research and clinical oncology. 2008 ; Vol. 134, No. 12. pp. 1267-1276.

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abstract = "Purpose and methods: Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs. Results: Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival. Conclusions: The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.",

keywords = "14q, D14S67, D14S995, Head and neck squamous cell carcinoma, Loss of heterozygosity, Microsatellite marker, Survival",

author = "Davut Pehlivan and Esra Gunduz and Mehmet Gunduz and Hitoshi Nagatsuka and Beder, {Levent Bekir} and Beyhan Cengiz and Rivera, {Rosario S.} and Kunihiro Fukushima and Sukru Palanduz and Sukru Ozturk and Noboru Yamanaka and Kenji Shimizu",

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AU - Pehlivan, Davut

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AU - Gunduz, Mehmet

AU - Nagatsuka, Hitoshi

AU - Beder, Levent Bekir

AU - Cengiz, Beyhan

AU - Rivera, Rosario S.

AU - Fukushima, Kunihiro

AU - Palanduz, Sukru

AU - Ozturk, Sukru

AU - Yamanaka, Noboru

AU - Shimizu, Kenji

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AB - Purpose and methods: Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs. Results: Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival. Conclusions: The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.

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