Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas

Davut Pehlivan, Esra Gunduz, Mehmet Gunduz, Hitoshi Nagatsuka, Levent Bekir Beder, Beyhan Cengiz, Rosario S. Rivera, Kunihiro Fukushima, Sukru Palanduz, Sukru Ozturk, Noboru Yamanaka, Kenji Shimizu

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14 Citations (Scopus)

Abstract

Purpose and methods: Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs. Results: Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival. Conclusions: The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.

Original languageEnglish
Pages (from-to)1267-1276
Number of pages10
JournalJournal of cancer research and clinical oncology
Volume134
Issue number12
DOIs
Publication statusPublished - Dec 2008

Keywords

  • 14q
  • D14S67
  • D14S995
  • Head and neck squamous cell carcinoma
  • Loss of heterozygosity
  • Microsatellite marker
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Pehlivan, D., Gunduz, E., Gunduz, M., Nagatsuka, H., Beder, L. B., Cengiz, B., Rivera, R. S., Fukushima, K., Palanduz, S., Ozturk, S., Yamanaka, N., & Shimizu, K. (2008). Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas. Journal of cancer research and clinical oncology, 134(12), 1267-1276. https://doi.org/10.1007/s00432-008-0423-1